5FJH

Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino) -2-oxoethyl)amino)methyl)isonicotinic acid

Summary for 5FJH

• Entry DOI: 10.2210/pdb5fjh/pdb
• Related: 5FJK
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4C, NICKEL (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ... (7 entities in total)
• Functional Keywords: oxidoreductase, transcription regulation, metal binding, demethylase, lysine-specific demethylase 4c
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : Q9H3R0
• Total number of polymer chains: 2
• Total formula weight: 82028.39

Authors

Cecatiello, V.,Pasqualato, S. (deposition date: 2015-10-09, release date: 2015-10-21, Last modification date: 2024-01-10)

• Primary citation: Cecatiello, V.,Pasqualato, S.; Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)