Author results

4TVP
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CRYSTAL STRUCTURE OF THE HIV-1 BG505 SOSIP.664 ENV TRIMER ECTODOMAIN, COMPRISING ATOMIC-LEVEL DEFINITION OF PRE-FUSION GP120 AND GP41, IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22
Descriptor:Envelope glycoprotein gp160, PGT122 Light chain, PGT122 Heavy chain, ...
Authors:Pancera, M., Zhou, T., Kwong, P.D.
Deposit date:2014-06-27
Release date:2014-10-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Nature, 514, 2014
3JWD
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3JWO
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Huang, C.C., Kwon, Y.D., Zhou, T., Robinson, J.E., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LRS
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STRUCTURE OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV-1
Descriptor:PG-16 Heavy Chain Fab, PG-16 Light Chain Fab, N-ACETYL-D-GLUCOSAMINE
Authors:Pancera, M., Kwong, P.D.
Deposit date:2010-02-11
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010
3MME
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STRUCTURE AND FUNCTIONAL DISSECTION OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV-1
Descriptor:PG16 HEAVY CHAIN FAB, PG16 LIGHT CHAIN FAB, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P.
Deposit date:2010-04-19
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010
4DQO
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CRYSTAL STRUCTURE OF PG16 FAB IN COMPLEX WITH V1V2 REGION FROM HIV-1 STRAIN ZM109
Descriptor:PG16 Fab Heavy Chain, PG16 Fab Light Chain, 1FD6-V1V2 scaffold ZM109 HIV-1 strain, ...
Authors:Pancera, M., McLellan, J.S., Kwong, P.D.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.438 Å)
Cite:Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Nat.Struct.Mol.Biol., 20, 2013
5U7M
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-378806 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 FAB HEAVY CHAIN, 35O22 FAB LIGHT CHAIN, ...
Authors:Pancera, M., Lai, Y.-T., Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.025 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
5U7O
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-626529 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 FAB HEAVY CHAIN, 35O22 FAB LIGHT CHAIN, ...
Authors:Pancera, M., Lai, Y.-T., Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.031 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
3U4B
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CH04H/CH02L FAB P4
Descriptor:CH04 Heavy chain, CH02 Light chain
Authors:Pancera, M., Louder, R., Mclellan, J.S., KWong, P.D.
Deposit date:2011-10-07
Release date:2011-11-30
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (2.893 Å)
Cite:Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
4TOY
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STRUCTURE OF 35O22 FAB, A HIV-1 NEUTRALIZING ANTIBODY
Descriptor:35O22 Fab Heavy chain, 35O22 Fab Light chain
Authors:Pancera, M., Kwong, P.D.
Deposit date:2014-06-06
Release date:2014-09-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
Nature, 515, 2014
5UTF
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CRYSTAL STRUCTURE OF A STABILIZED DS-SOSIP.6MUT BG505 GP140 HIV-1 ENV TRIMER, CONTAINING MUTATIONS I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 4.3 A
Descriptor:Envelope glycoprotein gp120, Envelope glycoprotein gp41, PGT122 Light chain, ...
Authors:Pancera, M., Chuang, G.-Y., Xu, K., Kwong, P.D.
Deposit date:2017-02-14
Release date:2017-03-29
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
J. Virol., 91, 2017
6B5L
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STRUCTURE OF PFCSP PEPTIDE 20 WITH HUMAN PROTECTIVE ANTIBODY CIS43
Descriptor:CIS43 Fab Heavy chain, CIS43 Fab Light Chain, PfCSP peptide 20: ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5M
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STRUCTURE OF PFCSP PEPTIDE 21 WITH HUMAN PROTECTIVE ANTIBODY CIS43
Descriptor:CIS43 Fab Heavy chain, CIS43 Fab Light chain, pfCSP peptide 21: ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN, ...
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5N
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STRUCTURE OF PFCSP PEPTIDE 25 WITH HUMAN PROTECTIVE ANTIBODY CIS43
Descriptor:CIS43 Fab Heavy chain, CIS43 Fab Light chain, pfCSP peptide 25: ASN-VAL-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5O
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STRUCTURE OF PFCSP PEPTIDE 29 WITH HUMAN PROTECTIVE ANTIBODY CIS43
Descriptor:CIS43 Fab Heavy chain, CIS43 Fab Light chain, PfCSP peptide 29: ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5P
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STRUCTURE OF PFCSP PEPTIDE 20 WITH HUMAN ANTIBODY CIS42
Descriptor:pfCSP peptide 20: ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP, CIS42 Fab Heavy chain, CIS42 Fab Light chain
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5R
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STRUCTURE OF PFCSP PEPTIDE 21 WITH HUMAN ANTIBODY CIS42
Descriptor:CIS42 Fab Heavy chain, CIS42 Fab Light chain, PfCSP peptide 21: ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.775 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5S
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STRUCTURE OF PFCSP PEPTIDE 25 WITH HUMAN ANTIBODY CIS42
Descriptor:CIS42 Fab Heavy chain, CIS42 Fab Light chain, pfCSP peptide 25: ASN-VAL-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN, ...
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
6B5T
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STRUCTURE OF PFCSP PEPTIDE 29 WITH HUMAN ANTIBODY CIS42
Descriptor:pfCSP peptide 29: ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA, CIS42 Fab Heavy chain, CIS42 Fab Light chain, ...
Authors:Pancera, M., Weidle, C.
Deposit date:2017-09-29
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24, 2018
5TF1
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STRUCTURE OF CHIMERIC 02-CC FAB, A VRC01-LIKE GERMLINE ANTIBODY
Descriptor:02-CC Fab Heavy chain, O2-CC Fab Light Chain
Authors:Pancera, M.
Deposit date:2016-09-23
Release date:2016-11-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.858 Å)
Cite:Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.
Cell Rep, 17, 2016
5TFS
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STRUCTURE OF CHIMERIC 02-K FAB, A VRC01-LIKE GERMLINE ANTIBODY
Descriptor:02-K Fab Heavy chain, 02-K Fab Light chain, SULFATE ION
Authors:Pancera, M.
Deposit date:2016-09-26
Release date:2016-11-09
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.
Cell Rep, 17, 2016
5TGB
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STRUCTURE OF CHIMERIC 02-CB FAB, A VRC01-LIKE GERMLINE ANTIBODY
Descriptor:02-CB Fab Heavy Chain, 02-CB Fab Light Chain
Authors:Pancera, M.
Deposit date:2016-09-27
Release date:2016-11-09
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.741 Å)
Cite:Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.
Cell Rep, 17, 2016
6BLA
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STRUCTURE OF AMM01 FAB, AN ANTI EBV GH/GL NEUTRALIZING ANTIBODY
Descriptor:AMM01 Fab Heavy chain, AMM01 Fab Light chain, 1,2-ETHANEDIOL, ...
Authors:Pancera, M., Weidle, C.
Deposit date:2017-11-09
Release date:2018-04-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.
Immunity, 48, 2018
3HI1
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STRUCTURE OF HIV-1 GP120 (CORE WITH V3) IN COMPLEX WITH CD4-BINDING-SITE ANTIBODY F105
Descriptor:Glycoprotein 120, F105 Light Chain, F105 Heavy Chain, ...
Authors:Kwon, Y.D., Chen, L., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z., Zhang, M.-Y., Arthos, J., Burton, D.R., Dimitrov, D., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D.
Deposit date:2009-05-18
Release date:2009-11-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science, 326, 2009
3IDX
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CRYSTAL STRUCTURE OF HIV-GP120 CORE IN COMPLEX WITH CD4-BINDING SITE ANTIBODY B13, SPACE GROUP C222
Descriptor:HIV-1 HxBc2 gp120 core, Fab b13 heavy chain, Fab b13 light chain, ...
Authors:Chen, L., Kwon, Y.D., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z.Y., Zhang, M.Y., Arthos, J., Burton, D.R., Dimitrov, D.S., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D.
Deposit date:2009-07-22
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science, 326, 2009