6B5L

Structure of PfCSP peptide 20 with human protective antibody CIS43

Summary for 6B5L

DescriptorCIS43 Fab Heavy chain, CIS43 Fab Light Chain, PfCSP peptide 20: ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL, ... (4 entities in total)
Functional Keywordsmalaria, pfcsp, vaccine, antibodies, immune system
Biological sourceHomo sapiens
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Total number of polymer chains3
Total molecular weight49528.12
Authors
Pancera, M.,Weidle, C. (deposition date: 2017-09-29, release date: 2018-03-21, Last modification date: 2018-04-25)
Primary citation
Kisalu, N.K.,Idris, A.H.,Weidle, C.,Flores-Garcia, Y.,Flynn, B.J.,Sack, B.K.,Murphy, S.,Schon, A.,Freire, E.,Francica, J.R.,Miller, A.B.,Gregory, J.,March, S.,Liao, H.X.,Haynes, B.F.,Wiehe, K.,Trama, A.M.,Saunders, K.O.,Gladden, M.A.,Monroe, A.,Bonsignori, M.,Kanekiyo, M.,Wheatley, A.K.,McDermott, A.B.,Farney, S.K.,Chuang, G.Y.,Zhang, B.,Kc, N.,Chakravarty, S.,Kwong, P.D.,Sinnis, P.,Bhatia, S.N.,Kappe, S.H.I.,Sim, B.K.L.,Hoffman, S.L.,Zavala, F.,Pancera, M.,Seder, R.A.
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Nat. Med., 24:408-416, 2018
PubMed: 29554083 (PDB entries with the same primary citation)
DOI: 10.1038/nm.4512
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238300.5%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution