5U7M

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom

Summary for 5U7M

• Entry DOI: 10.2210/pdb5u7m/pdb
• Related: 5U7O
• Descriptor: Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• Functional Keywords: hiv-1 entry, small molecule, inhibitor, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 180977.01

Authors

Pancera, M.,Lai, Y.-T.,Kwong, P.D. (deposition date: 2016-12-12, release date: 2017-08-30, Last modification date: 2020-07-29)

• Primary citation: Pancera, M.,Lai, Y.T.,Bylund, T.,Druz, A.,Narpala, S.,O'Dell, S.,Schon, A.,Bailer, R.T.,Chuang, G.Y.,Geng, H.,Louder, M.K.,Rawi, R.,Soumana, D.I.,Finzi, A.,Herschhorn, A.,Madani, N.,Sodroski, J.,Freire, E.,Langley, D.R.,Mascola, J.R.,McDermott, A.B.,Kwong, P.D.; Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.; Nat. Chem. Biol., 13:1115-1122, 2017; PubMed: 28825711; DOI: 10.1038/nchembio.2460

Experimental method

X-RAY DIFFRACTION (3.025 Å)