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1C50
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IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE
Authors:Oikonomakos, N.G., Skamnaki, V.T., Tsitsanou, K.E., Gavalas, N.G., Johnson, L.N.
Deposit date:1999-12-15
Release date:1999-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
Structure Fold.Des., 8, 2000
1WUY
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-09
Release date:2005-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
1WV0
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-10
Release date:2005-12-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
1WV1
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGENPHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-10
Release date:2005-12-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
1GFZ
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, INOSINIC ACID, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-06-29
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
1KTI
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BINDING OF 100 MM N-ACETYL-N'-BETA-D-GLUCOPYRANOSYL UREA TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUDIES
Descriptor:GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-ACETYL-N'-BETA-D-GLUCOPYRANOSYL UREA, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M., Zographos, S.E., Leonidas, D.D., Chrysina, E.D., Somsak, L., Nagy, V., Praly, J.P., Docsa, T., Toth, B., Gergely, P.
Deposit date:2002-01-16
Release date:2002-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Binding of N-acetyl-N'-beta-D-glucopyranosyl urea and N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
Eur.J.Biochem., 269, 2002
1C8K
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
1E1Y
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-17
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site
J.Biol.Chem., 275, 2000
1HLF
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BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD
Descriptor:GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, 8,9,10-TRIHYDROXY-7-HYDROXYMETHYL-2-THIOXO-6-OXA-1,3-DIAZA-SPIRO[4.5]DECAN-4-ONE
Authors:Oikonomakos, N.G., Skamnaki, V.T., Docsa, T., Toth, B., Gergely, P., Osz, E., Szilagyi, L., Somsak, L.
Deposit date:2000-12-01
Release date:2000-12-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B
BIOORG.MED.CHEM., 10, 2002
2GPA
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ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), ALPHA-D-GLUCOSE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Tsitsanou, K.E., Zographos, S.E., Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
3AMV
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ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), ALPHA-D-GLUCOSE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Tsitsanou, K.E., Zographos, S.E., Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
1H5U
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THE 1.76 A RESOLUTION CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH GLUCOSE AND CP320626, A POTENTIAL ANTIDIABETIC DRUG
Descriptor:GLYCOGEN PHOSPHORYLASE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, ALPHA-D-GLUCOSE, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Archontis, G.
Deposit date:2001-05-25
Release date:2001-06-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and Cp320626, a Potential Antidiabetic Drug
Bioorg.Med.Chem., 10, 2002
1K06
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CRYSTALLOGRAPHIC BINDING STUDY OF 100 MM N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA TO GLYCOGEN PHOSPHORYLASE B
Descriptor:Glycogen Phosphorylase, N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA, PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G., Kosmopoulou, M., Zographos, S.E., Leonidas, D.D., Chrysina, E.D., Somsak, L., Nagy, V., Praly, J.P., Docsa, T., Toth, B., Gergely, P.
Deposit date:2001-09-18
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
Eur.J.Biochem., 269, 2002
1K08
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CRYSTALLOGRAPHIC BINDING STUDY OF 10 MM N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA TO GLYCOGEN PHOSPHORYLASE B
Descriptor:Glycogen Phosphorylase, N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA, PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G., Kosmopoulou, M., Zographos, S.E., Leonidas, D.D., Chrysina, E.D., Somsak, L., Nagy, V., Praly, J.P., Docsa, T., Toth, B., Gergely, P.
Deposit date:2001-09-18
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
Eur.J.Biochem., 269, 2002
1LWN
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE A IN COMPLEX WITH A POTENTIAL HYPOGLYCAEMIC DRUG AT 2.0 A RESOLUTION
Descriptor:glycogen phosphorylase, ALPHA-D-GLUCOSE, PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G., Chrysina, E.D., Kosmopoulou, M., Leonidas, D.D.
Deposit date:2002-06-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS, 1647, 2003
1LWO
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE A IN COMPLEX WITH A POTENTIAL HYPOGLYCAEMIC DRUG AT 2.0 A RESOLUTION
Descriptor:glycogen phosphorylase, ALPHA-D-GLUCOSE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D.
Deposit date:2002-06-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS, 1647, 2003
2PRI
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BINDING OF 2-DEOXY-GLUCOSE-6-PHOSPHATE TO GLYCOGEN PHOSPHORYLASE B
Descriptor:GLYCOGEN PHOSPHORYLASE B, 2-deoxy-6-O-phosphono-alpha-D-arabino-hexopyranose, PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G., Zographos, S.E., Johnson, L.N., Papageorgiou, A.C., Acharya, K.R.
Deposit date:1998-12-11
Release date:1998-12-14
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies.
J.Mol.Biol., 254, 1995
2PRJ
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BINDING OF N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE TO GLYCOGEN PHOSPHORYLASE B
Descriptor:GLYCOGEN PHOSPHORYLASE, 1-N-ACETYL-BETA-D-GLUCOSAMINE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kontou, M., Zographos, S.E., Watson, K.A., Johnson, L.N., Bichard, C.J.F., Fleet, G.W.J., Acharya, K.R.
Deposit date:1998-12-11
Release date:1998-12-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
Protein Sci., 4, 1995
2G9Q
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THE CRYSTAL STRUCTURE OF THE GLYCOGEN PHOSPHORYLASE B- 1AB COMPLEX
Descriptor:Glycogen phosphorylase, muscle form, PHOSPHATE ION, ...
Authors:Oikonomakos, N.G., Tiraidis, C., Leonidas, D.D., Zographos, S.E., Kristiansen, M., Agius, L.
Deposit date:2006-03-07
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
J.Med.Chem., 49, 2006
2G9R
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THE CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH (3R,4R,5R)-5-HYDROXYMETHYL-1-(3-PHENYLPROPYL)-PIPERIDINE-3,4-DIOL
Descriptor:Glycogen phosphorylase, muscle form, (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL
Authors:Oikonomakos, N.G., Tiraidis, C., Leonidas, D.D., Zographos, S.E.
Deposit date:2006-03-07
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
J.Med.Chem., 49, 2006
2G9U
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THE CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH (3R,4R,5R)-5-HYDROXYMETHYL-1-(3-PHENYLPROPYL)-PIPERIDINE-3,4-DIOL AND PHOSPHATE
Descriptor:Glycogen phosphorylase, muscle form, PHOSPHATE ION, ...
Authors:Oikonomakos, N.G., Tiraidis, C., Leonidas, D.D., Zographos, S.E.
Deposit date:2006-03-07
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
J.Med.Chem., 49, 2006
2G9V
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THE CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH (3R,4R,5R)-5-HYDROXYMETHYLPIPERIDINE-3,4-DIOL AND PHOSPHATE
Descriptor:Glycogen phosphorylase, muscle form, PHOSPHATE ION, ...
Authors:Oikonomakos, N.G., Tiraidis, C., Leonidas, D.D., Zographos, S.E.
Deposit date:2006-03-07
Release date:2007-01-16
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
J.Med.Chem., 49, 2006
2SKC
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PYRIDOXAL PHOSPHORYLASE B IN COMPLEX WITH FLUOROPHOSPHATE, GLUCOSE AND INOSINE-5'-MONOPHOSPHATE
Descriptor:PYRIDOXAL PHOSPHORYLASE B, ALPHA-D-GLUCOSE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Tsitsanou, K.E., Johnson, L.N., Acharya, K.R.
Deposit date:1998-12-11
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal.
Protein Sci., 5, 1996
2SKD
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PYRIDOXAL PHOSPHORYLASE B IN COMPLEX WITH PHOSPHATE, GLUCOSE AND INOSINE-5'-MONOPHOSPHATE
Descriptor:PYRIDOXAL PHOSPHORYLASE B, ALPHA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Tsitsanou, K.E., Johnson, L.N., Acharya, K.R.
Deposit date:1998-12-11
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal.
Protein Sci., 5, 1996
2SKE
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PYRIDOXAL PHOSPHORYLASE B IN COMPLEX WITH PHOSPHITE, GLUCOSE AND INOSINE-5'-MONOPHOSPHATE
Descriptor:PYRIDOXAL PHOSPHORYLASE B, ALPHA-D-GLUCOSE, PHOSPHITE ION, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Tsitsanou, K.E., Johnson, L.N., Acharya, K.R.
Deposit date:1998-12-11
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal.
Protein Sci., 5, 1996