1WV1

Crystallographic studies on acyl ureas, a new class of inhibitors of glycogenphosphorylase. Broad specificity of the allosteric site

Summary for 1WV1

Entry DOI	10.2210/pdb1wv1/pdb
Related	1WUT 1WUY 1WV0 3AMV
Descriptor	Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, 5-[3-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2-METHYLPHENOXY]PENTANOIC ACID, ... (4 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, transferase
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	97977.63
Authors	Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Klabunde, T.,Wendt, K.U.,Defossa, E. (deposition date: 2004-12-10, release date: 2005-12-10, Last modification date: 2011-07-13)
Primary citation	Oikonomakos, N.G.,Kosmopoulou, M.N.,Chrysina, E.D.,Leonidas, D.D.,Kostas, I.D.,Wendt, K.U.,Klabunde, T.,Defossa, E. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14:1760-1771, 2005 Cited by PubMed: 15987904 DOI: 10.1110/ps.051432405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation