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3Q9U
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BU of 3q9u by Molmil
In silico and in vitro co-evolution of a high affinity complementary protein-protein interface
Descriptor: COENZYME A, CoA binding protein, consensus ankyrin repeat
Authors:Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC)
Deposit date:2011-01-10
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
3Q9N
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BU of 3q9n by Molmil
In silico and in vitro co-evolution of a high affinity complementary protein-protein interface
Descriptor: CARBAMOYL SARCOSINE, COENZYME A, CoA binding protein, ...
Authors:Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC)
Deposit date:2011-01-09
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
5IXE
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BU of 5ixe by Molmil
1.75A RESOLUTION STRUCTURE OF 5-Fluoroindole BOUND BETA-GLYCOSIDASE (W33G) FROM SULFOLOBUS SOLFATARICUS
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-fluoro-1H-indole, Beta-galactosidase, ...
Authors:Lovell, S, Battaile, K.P, Mehzabeen, N, Budiardjo, S.J, Karanicolas, J.
Deposit date:2016-03-23
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Full and Partial Agonism of a Designed Enzyme Switch.
ACS Synth Biol, 5, 2016
8E7B
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BU of 8e7b by Molmil
Crystal structure of the p53 (Y107H) core domain monoclinic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
8E7A
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BU of 8e7a by Molmil
Crystal structure of the p53 (Y107H) core domain orthorhombic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
4LQU
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BU of 4lqu by Molmil
1.60A resolution crystal structure of a superfolder green fluorescent protein (W57G) mutant
Descriptor: Green fluorescent protein
Authors:Lovell, S, Xia, Y, Vo, B, Battaile, K.P, Egan, C, Karanicolas, J.
Deposit date:2013-07-19
Release date:2013-12-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation.
J.Am.Chem.Soc., 135, 2013
4LQT
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BU of 4lqt by Molmil
1.10A resolution crystal structure of a superfolder green fluorescent protein (W57A) mutant
Descriptor: 1,2-ETHANEDIOL, Green fluorescent protein
Authors:Lovell, S, Xia, Y, Vo, B, Battaile, K.P, Egan, C, Karanicolas, J.
Deposit date:2013-07-19
Release date:2013-12-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation.
J.Am.Chem.Soc., 135, 2013
4EAN
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BU of 4ean by Molmil
1.75A resolution structure of indole bound beta-glycosidase (W33G) from sulfolobus solfataricus
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-galactosidase, CHLORIDE ION, ...
Authors:Lovell, S, Battaile, K.P, Deckert, K, Brunner, L.C, Budiardjo, S.J, Karanicolas, J.
Deposit date:2012-03-22
Release date:2012-06-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Designing allosteric control into enzymes by chemical rescue of structure.
J.Am.Chem.Soc., 134, 2012
4EAM
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BU of 4eam by Molmil
1.70A resolution structure of apo beta-glycosidase (W33G) from sulfolobus solfataricus
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-galactosidase, ...
Authors:Lovell, S, Battaile, K.P, Deckert, K, Brunner, L.C, Budiardjo, S.J, Karanicolas, J.
Deposit date:2012-03-22
Release date:2012-06-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Designing allosteric control into enzymes by chemical rescue of structure.
J.Am.Chem.Soc., 134, 2012
2NQQ
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BU of 2nqq by Molmil
MoeA R137Q
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NRS
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BU of 2nrs by Molmil
MoeA S371W
Descriptor: Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-11-02
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NRP
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BU of 2nrp by Molmil
MoeA R350A
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-11-02
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NRO
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BU of 2nro by Molmil
MoeA K279Q
Descriptor: Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-11-02
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NQK
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BU of 2nqk by Molmil
MoeA D59N mutant
Descriptor: Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NQS
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BU of 2nqs by Molmil
MoeA E188A
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NQU
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BU of 2nqu by Molmil
MoeA E188Q
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NQN
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BU of 2nqn by Molmil
MoeA T100W
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NQR
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BU of 2nqr by Molmil
MoeA D142N
Descriptor: GLYCEROL, Molybdopterin biosynthesis protein moeA
Authors:Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
Deposit date:2006-10-31
Release date:2007-01-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
3QA9
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BU of 3qa9 by Molmil
Crystal Structure of Prb (PH1109 protein redesigned for binding)
Descriptor: CoA binding domain protein
Authors:Spiegel, P.C.
Deposit date:2011-01-10
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
4UYN
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BU of 4uyn by Molmil
SAR156497 an exquisitely selective inhibitor of Aurora kinases
Descriptor: AURORA KINASE A, ethyl (9S)-9-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-8-hydroxy-5,6,7,9-tetrahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate
Authors:Carry, J.C, Clerc, F, Minoux, H, Schio, L, Mauger, J, Nair, A, Parmantier, E, Lemoigne, R, Delorme, C, Nicolas, J.P, Krick, A, Abecassis, P.Y, Crocq-Stuerga, V, Pouzieux, S, Delarbre, L, Maignan, S, Bertrand, T, Bjergarde, K, Ma, N, Lachaud, S, Guizani, H, Lebel, R, Doerflinger, G, Monget, S, Perron, S, Gasse, F, Angouillant-Boniface, O, Filoche-Romme, B, Murer, M, Gontier, S, Prevost, C, Monteiro, M.L, Combeau, C.
Deposit date:2014-09-02
Release date:2014-11-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Sar156497, an Exquisitely Selective Inhibitor of Aurora Kinases.
J.Med.Chem., 58, 2015
4BFR
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BU of 4bfr by Molmil
Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
Descriptor: 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC S SUBUNIT BETA ISOFORM
Authors:Certal, V, Carry, J.C, Halley, F, Virone-Oddos, A, Thompson, F, Filoche-Romme, B, El-Ahmad, Y, Karlsson, A, Charrier, V, Delorme, C, Rak, A, Abecassis, P.Y, Amara, C, Vincent, L, Bonnevaux, H, Nicolas, J.P, Mathieu, M, Bertrand, T, Marquette, J.P, Michot, N, Benard, T, Perrin, M.A, Perron, S, Monget, S, Gruss-Leleu, F, Doerflinger, G, Guizani, H, Brollo, M, Delbarre, L, Bertin, L, Richepin, P, Loyau, V, Garcia-Echeverria, C, Lengauer, C, Schio, L.
Deposit date:2013-03-22
Release date:2014-01-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
J.Med.Chem., 57, 2014
6W9E
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BU of 6w9e by Molmil
Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295
Descriptor: (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, Cyclin-T1, ...
Authors:Zhang, P, Wu, J.
Deposit date:2020-03-22
Release date:2021-09-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships
To Be Published
3PPD
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BU of 3ppd by Molmil
GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection
Descriptor: ACETIC ACID, GGVLVN peptide, amyloid forming segment, ...
Authors:Zhao, A, Sawaya, M.R, Eisenberg, D.
Deposit date:2010-11-24
Release date:2011-06-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.
Nature, 475, 2011
6CWG
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BU of 6cwg by Molmil
Ricin catalytic subunit bound go A9 VHH antibody
Descriptor: CHLORIDE ION, Ricin, VHH antibody
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2018-03-30
Release date:2019-01-16
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
6CWK
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BU of 6cwk by Molmil
Anti-RTA VHH antibody
Descriptor: 1,2-ETHANEDIOL, Anti-Ricin antibody, CHLORIDE ION, ...
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2018-03-30
Release date:2019-01-16
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.256 Å)
Cite:Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018

 

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