Author results

4F7B
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STRUCTURE OF THE LYSOSOMAL DOMAIN OF LIMP-2
Descriptor:Lysosome membrane protein 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Neculai, D., Ravichandran, M., Seitova, A., Neculai, M., Pizzaro, J.C., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Dhe-Paganon, D., Structural Genomics Consortium (SGC)
Deposit date:2012-05-15
Release date:2013-10-09
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
Nature, 504, 2013
1Y1U
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STRUCTURE OF UNPHOSPHORYLATED STAT5A
Descriptor:Signal transducer and activator of transcription 5A
Authors:Neculai, D., Neculai, A.M., Verrier, S., Straub, K., Klumpp, K., Pfitzner, E., Becker, S.
Deposit date:2004-11-19
Release date:2005-10-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structure of the unphosphorylated STAT5a dimer
J.Biol.Chem., 280, 2005
3IV1
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COILED-COIL DOMAIN OF TUMOR SUSCEPTIBILITY GENE 101
Descriptor:Tumor susceptibility gene 101 protein, SULFATE ION, CHLORIDE ION
Authors:Neculai, D., Avvakumov, G.V., Wernimont, A.K., Xue, S., Walker, J.R., Li, Y., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-08-31
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Coiled-Coil Domain of Human Tsg101
To be Published
5BNH
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CRYSTAL STRUCTURE OF THE HLTF HIRAN DOMAIN WITH A SSDNA FRAGMENT
Descriptor:DNA (5'-D(*(GD)P*GP*TP*G)-3'), DNA (5'-D(*(TD)P*TP*G)-3'), Helicase-like transcription factor, ...
Authors:Neculai, D., Walker, J.R., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Dhe-Paganon, S.
Deposit date:2015-05-26
Release date:2016-05-25
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Co-crystal structure of the HLTF HIRAN domain with a ssDNA fragment
To Be Published
3I3T
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CRYSTAL STRUCTURE OF COVALENT UBIQUITIN-USP21 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 21, Ubiquitin, ZINC ION, ...
Authors:Neculai, D., Avvakumov, G.V., Walker, J.R., Xue, S., Butler-Cole, C., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-07-21
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
2P64
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D DOMAIN OF B-TRCP
Descriptor:F-box/WD repeat protein 1A, CADMIUM ION
Authors:Neculai, D., Orlicky, S., Ceccarelli, D.
Deposit date:2007-03-16
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Cell(Cambridge,Mass.), 129, 2007
4K25
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CRYSTAL STRUCTURE OF YEAST QRI7 HOMODIMER
Descriptor:Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ZINC ION, ...
Authors:Neculai, D., Wan, L., Mao, D.Y., Sicheri, F.
Deposit date:2013-04-08
Release date:2013-05-08
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Res., 41, 2013
3EN9
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STRUCTURE OF THE METHANOCOCCUS JANNASCHII KAE1-BUD32 FUSION PROTEIN
Descriptor:O-sialoglycoprotein endopeptidase/protein kinase, MAGNESIUM ION, HEXATANTALUM DODECABROMIDE
Authors:Neculai, D.
Deposit date:2008-09-25
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
3ENC
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CRYSTAL STRUCTURE OF PYROCOCCUS FURIOSUS PCC1 DIMER
Descriptor:protein PCC1
Authors:Neculai, D.
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6304 Å)
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
3ENH
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CRYSTAL STRUCTURE OF CGI121/BUD32/KAE1 COMPLEX
Descriptor:Putative O-sialoglycoprotein endopeptidase, Uncharacterized protein MJ0187, HEXATANTALUM DODECABROMIDE
Authors:Neculai, D.
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine
Mol.Cell, 32, 2008
3ENO
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CRYSTAL STRUCTURE OF PYROCOCCUS FURIOSUS PCC1 IN COMPLEX WITH THERMOPLASMA ACIDOPHILUM KAE1
Descriptor:Putative O-sialoglycoprotein endopeptidase, uncharacterized protein PF2011, MAGNESIUM ION
Authors:Neculai, D.
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.0201 Å)
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
2OB4
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HUMAN UBIQUITIN-CONJUGATING ENZYME CDC34
Descriptor:Ubiquitin-conjugating enzyme E2-32 kDa complementing
Authors:Neculai, D., Avvakumov, G.V., Xue, S., Walker, J.R., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Sicheri, F., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-12-18
Release date:2006-12-26
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
2QGX
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UBIQUITIN-CONJUGATING ENZYME E2Q
Descriptor:Ubiquitin-conjugating enzyme E2 Q1
Authors:Neculai, D., Avvakumov, G.V., Xue, S., Walker, J.R., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Sicheri, F., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-29
Release date:2008-03-18
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
3L11
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CRYSTAL STRUCTURE OF THE RING DOMAIN OF RNF168
Descriptor:E3 ubiquitin-protein ligase RNF168, ZINC ION, MALONATE ION
Authors:Neculai, D., Yermekbayeva, L., Crombet, L., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-12-10
Release date:2010-01-19
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287, 2012
1X6M
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CRYSTAL STRUCTURE OF THE GLUTATHIONE-DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (GFA)
Descriptor:Glutathione-dependent formaldehyde-activating enzyme, ZINC ION, SULFATE ION, ...
Authors:Neculai, A.M., Neculai, D., Vorholt, J.A., Becker, S.
Deposit date:2004-08-11
Release date:2004-11-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A dynamic zinc redox switch
J.Biol.Chem., 280, 2005
1XA8
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CRYSTAL STRUCTURE ANALYSIS OF GLUTATHIONE-DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (GFA)
Descriptor:Glutathione-dependent formaldehyde-activating enzyme, ZINC ION, SULFATE ION, ...
Authors:Neculai, A.M., Neculai, D., Griesinger, C., Vorholt, J.A., Becker, S.
Deposit date:2004-08-25
Release date:2004-11-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dynamic zinc redox switch
J.Biol.Chem., 280, 2005
2P63
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SUPRAFACIAL ORIENTATION OF THE SCFCDC4 DIMER ACCOMMODATES MULTIPLE GEOMETRIES FOR SUBSTRATE UBIQUITINATION
Descriptor:Cell division control protein 4
Authors:Orlicky, S., Neculai, D., Ceccarelli, D.
Deposit date:2007-03-16
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Cell(Cambridge,Mass.), 129, 2007
5K5F
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NMR STRUCTURE OF THE HLTF HIRAN DOMAIN
Descriptor:Helicase-like transcription factor
Authors:Bezsonova, I., Neculai, D., Korzhnev, D., Weigelt, J., Bountra, C., Edwards, A., Arrowsmith, C., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2016-05-23
Release date:2016-06-08
Method:SOLUTION NMR
Cite:NMR structure of the HLTF HIRAN domain
To Be Published
2K8Y
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SOLUTION NMR STRUCTURE OF CGI121 FROM METHANOCOCCUS JANNASCHII. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MJ0187
Descriptor:Uncharacterized protein MJ0187
Authors:Rumpel, S., Fares, C., Neculai, D., Arrowsmith, C., Montelione, G.T., Sicheri, F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-09-25
Release date:2008-11-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
3ENP
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CRYSTAL STRUCTURE OF HUMAN CGI121
Descriptor:TP53RK-binding protein
Authors:Haffani, Y.Z., Ceccarelli, D.F., Neculai, D., Mao, D.Y., Sicheri, F.
Deposit date:2008-09-25
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
2PBC
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FK506-BINDING PROTEIN 2
Descriptor:FK506-binding protein 2, DI(HYDROXYETHYL)ETHER
Authors:Walker, J.R., Neculai, D., Davis, T., Butler-Cole, C., Sicheri, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-28
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of FK506-Binding Protein 2
To be Published
2RIO
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STRUCTURE OF THE DUAL ENZYME IRE1 REVEALS THE BASIS FOR CATALYSIS AND REGULATION OF NON-CONVENTIONAL SPLICING
Descriptor:Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, STRONTIUM ION, ...
Authors:Lee, K.P., Dey, M., Neculai, D., Cao, C., Dever, T.E., Sicheri, F.
Deposit date:2007-10-12
Release date:2008-01-29
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.
Cell(Cambridge,Mass.), 132, 2008
3V6E
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CRYSTAL STRUCTURE OF USP2 AND A MUTANT FORM OF UBIQUITIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin, ZINC ION, ...
Authors:Neculai, M., Ernst, A., Sidhu, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2011-12-19
Release date:2012-12-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3MTN
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USP21 IN COMPLEX WITH A UBIQUITIN-BASED, USP21-SPECIFIC INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 21, UBIQUITIN VARIANT UBV.21.4, ZINC ION, ...
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3N3K
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THE CATALYTIC DOMAIN OF USP8 IN COMPLEX WITH A USP8 SPECIFIC INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Allali-Hassani, A., Lam, R., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2010-05-20
Release date:2010-06-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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