Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor

Summary for 3MTN

DescriptorUbiquitin carboxyl-terminal hydrolase 21, UBIQUITIN VARIANT UBV.21.4, ZINC ION, ... (6 entities in total)
Functional Keywordsubiquitin-specific protease activity, hydrolase, ubiquitin biology, structural genomics consortium, sgc, activator, chromatin regulator, nucleus, protease, thiol protease, transcription, transcription regulation, ubl conjugation pathway, isopeptide bond, phosphoprotein, inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9UK80
Total number of polymer chains4
Total molecular weight103043.34
Primary citation
Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.
A strategy for modulation of enzymes in the ubiquitin system.
Science, 339:590-595, 2013
PubMed: 23287719 (PDB entries with the same primary citation)
DOI: 10.1126/science.1230161
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26790.4%10.0%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report