Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| C | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| C | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 700 |
| Chain | Residue |
| A | CYS384 |
| A | CYS387 |
| A | CYS437 |
| A | CYS440 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 700 |
| Chain | Residue |
| C | CYS384 |
| C | CYS387 |
| C | CYS437 |
| C | CYS440 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| B | PHE68 |
| A | SER401 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 1 |
| Chain | Residue |
| C | HOH64 |
| C | SER401 |
| D | PHE68 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 563 |
| Chain | Residue |
| A | LYS360 |
| A | ARG454 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | GLU311 |
| A | HIS314 |
| A | ILE370 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 3 |
| Chain | Residue |
| C | GLU311 |
| C | HIS314 |
| C | ILE370 |
| C | VAL371 |
| D | GLY47 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 564 |
Functional Information from PROSITE/UniProt
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLrnlGNtCFLNAvLQ |
| Chain | Residue | Details |
| A | GLY213-GLN228 | |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YqLyALcnHsGsvhy..GHY |
| Chain | Residue | Details |
| A | TYR502-TYR519 | |
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| B | ARG54 | |
| B | ARG72 | |
| D | ARG54 | |
| D | ARG72 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| B | PHE68 | |
| D | PHE68 | |
| Chain | Residue | Details |
| B | SER65 | |
| D | SER65 | |
| A | CYS437 | |
| A | CYS440 | |
| C | CYS384 | |
| C | CYS387 | |
| C | CYS437 | |
| C | CYS440 | |
| Chain | Residue | Details |
| B | THR66 | |
| D | THR66 | |
| Chain | Residue | Details |
| B | GLY76 | |
| D | GLY76 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| B | LYS6 | |
| D | LYS6 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| B | GLY76 | |
| D | GLY76 | |
| Chain | Residue | Details |
| B | LYS11 | |
| B | LYS48 | |
| D | LYS11 | |
| D | LYS48 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| B | LYS27 | |
| D | LYS27 | |
| Chain | Residue | Details |
| B | LYS29 | |
| D | LYS29 | |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| B | LYS33 | |
| D | LYS33 | |
| Chain | Residue | Details |
| B | LYS63 | |
| D | LYS63 | |
