Author results

1JM4
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NMR STRUCTURE OF P/CAF BROMODOMAIN IN COMPLEX WITH HIV-1 TAT PEPTIDE
Descriptor:HIV-1 Tat Peptide, P300/CBP-associated Factor
Authors:Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.-M.
Deposit date:2001-07-17
Release date:2002-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002
1JSP
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NMR STRUCTURE OF CBP BROMODOMAIN IN COMPLEX WITH P53 PEPTIDE
Descriptor:tumor protein p53, CREB-BINDING PROTEIN
Authors:He, Y., Mujtaba, S., Zeng, L., Yan, S., Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
1WUG
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP1
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP2
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1XR0
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STRUCTURAL BASIS OF SNT PTB DOMAIN INTERACTIONS WITH DISTINCT NEUROTROPHIC RECEPTORS
Descriptor:Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1
Authors:Dhalluin, C., Yan, K.S., Plotnikova, O., Lee, K.W., Zeng, L., Kuti, M., Mujtaba, S., Goldfarb, M.P., Zhou, M.-M.
Deposit date:2004-10-13
Release date:2004-11-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Mol.Cell, 6, 2000
2L84
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SOLUTION NMR STRUCTURES OF CBP BROMODOMAIN WITH SMALL MOLECULE J28
Descriptor:CREB-binding protein, 5-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid
Authors:Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.
Deposit date:2011-01-03
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
2L85
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SOLUTION NMR STRUCTURES OF CBP BROMODOMAIN WITH SMALL MOLECULE OF HBS
Descriptor:CREB-binding protein, 4-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonic acid
Authors:Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
2RO1
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NMR SOLUTION STRUCTURES OF HUMAN KAP1 PHD FINGER-BROMODOMAIN
Descriptor:Transcription intermediary factor 1-beta, ZINC ION
Authors:Zeng, L., Yap, K.L., Ivanov, A.V., Wang, X., Mujtaba, S., Plotnikova, O., Rauscher, F.J.
Deposit date:2008-03-04
Release date:2008-05-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
2D82
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TARGET STRUCTURE-BASED DISCOVERY OF SMALL MOLECULES THAT BLOCK HUMAN P53 AND CREB BINDING PROTEIN (CBP) ASSOCIATION
Descriptor:CREB-binding protein, 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Authors:Sachchidanand, Resnick-Silverman, L., Yan, S., Mujtaba, S., Liu, W.J., Zeng, L., Manfredi, J.J., Zhou, M.M.
Deposit date:2005-12-01
Release date:2006-04-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
Chem.Biol., 13, 2006
2KVM
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SOLUTION STRUCTURE OF THE CBX7 CHROMODOMAIN IN COMPLEX WITH A H3K27ME2 PEPTIDE
Descriptor:Chromobox protein homolog 7, histone H3 peptide (residues 15-30) with dimethylated lysine 27
Authors:Yap, K.L., Zeng, L., Zhou, M.
Deposit date:2010-03-17
Release date:2010-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Mol.Cell, 38, 2010
1HZM
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STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
Authors:Farooq, A., Zhou, M.-M.
Deposit date:2001-01-25
Release date:2002-01-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Mol.Cell, 7, 2001
2MFQ
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NMR SOLUTION STRUCTURES OF FRS2A PTB DOMAIN WITH NEUROTROPHIN RECEPTOR TRKB
Descriptor:Fibroblast growth factor receptor substrate 2, BDNF/NT-3 growth factors receptor
Authors:Zeng, L., Zhou, M.
Deposit date:2013-10-18
Release date:2014-03-05
Last modified:2014-06-25
Method:SOLUTION NMR
Cite:Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.
Proteins, 82, 2014
4NUC
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS435 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUD
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS436 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS267 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
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