Author results

4AAB
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CRYSTAL STRUCTURE OF THE MUTANT D75N I-CREI IN COMPLEX WITH ITS WILD- TYPE TARGET (THE FOUR CENTRAL BASES, 2NN REGION, ARE COMPOSED BY GTAC FROM 5' TO 3')
Descriptor:DNA ENDONUCLEASE I-CREI, 14MER DNA 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', 10MER DNA 5'-D(*GP*AP*CP*GP*TP*TP*TP*TP*GP*AP)-3', ...
Authors:Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F.L., Epinat, J.C., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAD
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CRYSTAL STRUCTURE OF THE MUTANT D75N I-CREI IN COMPLEX WITH ITS WILD- TYPE TARGET IN ABSENCE OF METAL IONS AT THE ACTIVE SITE (THE FOUR CENTRAL BASES, 2NN REGION, ARE COMPOSED BY GTAC FROM 5' TO 3')
Descriptor:DNA ENDONUCLEASE I-CREI, 24MER DNA, GLYCEROL
Authors:Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F.L., Epinat, J.C., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAE
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CRYSTAL STRUCTURE OF THE MUTANT D75N I-CREI IN COMPLEX WITH AN ALTERED TARGET (THE FOUR CENTRAL BASES, 2NN REGION, ARE COMPOSED BY AGCG FROM 5' TO 3')
Descriptor:DNA ENDONUCLEASE I-CREI, 24MER DNA
Authors:Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F.L., Epinat, J.C., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAF
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CRYSTAL STRUCTURE OF THE MUTANT D75N I-CREI IN COMPLEX WITH AN ALTERED TARGET (THE FOUR CENTRAL BASES, 2NN REGION, ARE COMPOSED BY TGCA FROM 5' TO 3')
Descriptor:DNA ENDONUCLEASE I-CREI, 24MER DNA, 1,2-ETHANEDIOL
Authors:Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F.L., Epinat, J.C., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAG
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CRYSTAL STRUCTURE OF THE MUTANT D75N I-CREI IN COMPLEX WITH ITS WILD- TYPE TARGET IN PRESENCE OF CA AT THE ACTIVE SITE (THE FOUR CENTRAL BASES, 2NN REGION, ARE COMPOSED BY GTAC FROM 5' TO 3')
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP *GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', CALCIUM ION
Authors:Molina, R., Redondo, P., Stella, S., Marenchino, M., D'Abramo, M., Gervasio, F., Epinat, J.C., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4D6N
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 10 DAYS INCUBATION IN 5MM MG (STATE 7)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*DGP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*DAP)-3', 5'-D(*DGP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-11-13
Release date:2014-12-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4D6O
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 1H INCUBATION IN 5MM MG (STATE 2)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, MAGNESIUM ION, ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-11-13
Release date:2014-12-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UN7
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA BEFORE INCUBATION IN 5MM MN (STATE 1)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, ZINC ION
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2014-12-03
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UN8
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 1H INCUBATION IN 5MM MN (STATE 2)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, MANGANESE (II) ION
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2014-12-17
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UN9
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 8H INCUBATION IN 5MM MN (STATE 3)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, MANGANESE (II) ION
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2015-01-14
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.734 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UNA
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 2 DAYS INCUBATION IN 5MM MN (STATE 4)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2014-12-17
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UNB
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 6 DAYS INCUBATION IN 5MM MN (STATE 5)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*A)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2014-12-17
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UNC
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 8 DAYS INCUBATION IN 5MM MN (STATE 6)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*A)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-05-26
Release date:2014-12-17
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
4UT0
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THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH ITS TARGET DNA AT 10 DAYS INCUBATION IN 5MM MN (STATE 7)
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ...
Authors:Molina, R., Stella, S., Redondo, P., Gomez, H., Marcaida, M.J., Orozco, M., Prieto, J., Montoya, G.
Deposit date:2014-07-17
Release date:2014-12-17
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.
Nat.Struct.Mol.Biol., 22, 2015
5A0W
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THE CRYSTAL STRUCTURE OF I-DMOI E117A IN COMPLEX WITH ITS TARGET DNA AND IN THE PRESENCE OF 2MM MN
Descriptor:HOMING ENDONUCLEASE I-DMOI, 25MER, CHLORIDE ION, ...
Authors:Molina, R., Besker, N., Prieto, J., Montoya, G., D'Abramo, M.
Deposit date:2015-04-23
Release date:2016-05-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Dynamical Characterization of the I- Dmo Catalytic Activity
To be Published
5A72
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM CA
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*DTP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP *DCP*GP*AP*CP*GP*TP*TP*CP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A74
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM MN
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A77
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*DCP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A78
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA NOT CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5AK9
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THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF 2MM MN
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3, ...
Authors:Molina, R., Marcaida, M.J., Redondo, P., Marenchino, M., D'Abramo, M., Montoya, G., Prieto, J.
Deposit date:2015-03-02
Release date:2015-06-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AKF
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THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE CODING STRAND A AND IN THE PRESENCE OF 2MM MN
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ...
Authors:Molina, R., Marcaida, M.J., Redondo, P., Marenchino, M., D'Abramo, M., Montoya, G., Prieto, J.
Deposit date:2015-03-03
Release date:2015-06-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AKM
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THE CRYSTAL STRUCTURE OF I-DMOI G20S IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF 2MM MG
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ...
Authors:Molina, R., Marcaida, M.J., Redondo, P., Marenchino, M., D'Abramo, M., Montoya, G., Prieto, J.
Deposit date:2015-03-04
Release date:2015-06-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AKN
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THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE NON-CODING STRAND B AND IN THE PRESENCE OF 2MM MN
Descriptor:HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3, ...
Authors:Molina, R., Marcaida, M.J., Redondo, P., Marenchino, M., D'Abramo, M., Montoya, G., Prieto, J.
Deposit date:2015-03-04
Release date:2015-06-17
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
6QZQ
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CRYSTAL STRUCTURE OF CSX1 FROM SULFOLOBUS ISLANDICUS MONOCLINIC FORM
Descriptor:CRISPR-associated (Cas) DxTHG family
Authors:Molina, R., Montoya, G., Sofos, N., Stella, S.
Deposit date:2019-03-12
Release date:2020-01-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Type II CRISPR associated endoribonuclease SisCsx1 displays preferential cleavage and sequential cooperativity
To Be Published
6QZT
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CRYSTAL STRUCTURE OF CSX1 FROM SULFOLOBUS ISLANDICUS ORTHORHOMBIC FORM
Descriptor:CRISPR-associated (Cas) DxTHG family
Authors:Molina, R., Montoya, G., Sofos, N., Stella, S.
Deposit date:2019-03-12
Release date:2019-10-02
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structure of Csx1-cOA4complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.
Nat Commun, 10, 2019
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