Author results

2B0K
  • Download 2b0k
  • View 2b0k
Molmil generated image of 2b0k
CRYSTAL STRUCTURE OF THE DB921-D(CGCGAATTCGCG)2 COMPLEX.
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 2-(4'-AMIDINOBIPHENYL-4-YL)-1H-BENZIMIDAZOLE-5-AMIDINE
Authors:Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W., Wilson, W.D.
Deposit date:2005-09-14
Release date:2005-11-22
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of Heterocyclic Dications with the DNA Minor Groove.
Biochemistry, 44, 2005
5DX9
  • Download 5dx9
  • View 5dx9
Molmil generated image of 5dx9
STRUCTURE OF TREHALOSE-6-PHOSPHATE PHOSPHATASE FROM CRYPTOCOCCUS NEOFORMANS
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, Trehalose-6-phosphate, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXF
  • Download 5dxf
  • View 5dxf
Molmil generated image of 5dxf
STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE N-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.563 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXI
  • Download 5dxi
  • View 5dxi
Molmil generated image of 5dxi
STRUCTURE OF C. ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE C-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXL
  • Download 5dxl
  • View 5dxl
Molmil generated image of 5dxl
STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 1
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.573 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXN
  • Download 5dxn
  • View 5dxn
Molmil generated image of 5dxn
STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 2
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXO
  • Download 5dxo
  • View 5dxo
Molmil generated image of 5dxo
STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 3
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HUS
  • Download 5hus
  • View 5hus
Molmil generated image of 5hus
STRUCTURE OF CANDIDA ALBICANS TREHALOSE SYNTHASE REGULATORY PROTEIN C-TERMINAL DOMAIN
Descriptor:trehalose synthase regulatory protein
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structure of Candida albicans trehalose synthase regulatory protein C-terminal domain
To Be Published
5HUT
  • Download 5hut
  • View 5hut
Molmil generated image of 5hut
STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE, SULFATE ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUU
  • Download 5huu
  • View 5huu
Molmil generated image of 5huu
STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND GLUCOSE-6-PHOSPHATE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUV
  • Download 5huv
  • View 5huv
Molmil generated image of 5huv
STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE E341R/E346R IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose
To Be Published
5HVL
  • Download 5hvl
  • View 5hvl
Molmil generated image of 5hvl
STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVM
  • Download 5hvm
  • View 5hvm
Molmil generated image of 5hvm
STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE A IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.815 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVO
  • Download 5hvo
  • View 5hvo
Molmil generated image of 5hvo
STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE B IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.467 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
6NDZ
  • Download 6ndz
  • View 6ndz
Molmil generated image of 6ndz
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ8
Descriptor:Frizzled-8, Designed repeat binding protein, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-14
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.264 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE1
  • Download 6ne1
  • View 6ne1
Molmil generated image of 6ne1
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ4
Descriptor:Frizzled-4, Pfs, NACHT and Ankyrin domain protein, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE2
  • Download 6ne2
  • View 6ne2
Molmil generated image of 6ne2
DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ7
Descriptor:Designed repeat protein binder, Frizzled-7, ACETATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE4
  • Download 6ne4
  • View 6ne4
Molmil generated image of 6ne4
DESIGNED REPEAT PROTEIN SPECIFICALLY IN COMPLEX WITH FZ7CRD
Descriptor:Designed repeat binding protein, Frizzled-7, SULFATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-16
Release date:2019-05-15
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
3N6M
  • Download 3n6m
  • View 3n6m
Molmil generated image of 3n6m
CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH GTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6N
  • Download 3n6n
  • View 3n6n
Molmil generated image of 3n6n
CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH BR-UTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, 5-bromouridine 5'-(tetrahydrogen triphosphate)
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6L
  • Download 3n6l
  • View 3n6l
Molmil generated image of 3n6l
THE CRYSTAL STRUCUTRE OF RNA-DEPENDENT RNA POLYMERASE OF EV71 VIRUS
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION
Authors:Wu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
6MOI
  • Download 6moi
  • View 6moi
Molmil generated image of 6moi
DIMERIC DARPIN C_ANGLE_R5 COMPLEX WITH EPOR
Descriptor:Dimeric DARPing CCR5 (C_angle_R5), Erythropoietin receptor, SULFATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.065 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOK
  • Download 6mok
  • View 6mok
Molmil generated image of 6mok
DIMERIC DARPIN A_DISTANCE_R7 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (5.101 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOL
  • Download 6mol
  • View 6mol
Molmil generated image of 6mol
MONOEXTENDED DARPIN M_R12 COMPLEX WITH EPOR
Descriptor:Monoextended DARPin R12 (M_R12), Erythropoietin receptor, GLYCEROL
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.163 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOE
  • Download 6moe
  • View 6moe
Molmil generated image of 6moe
MONOMERIC DARPIN E2 COMPLEX WITH EPOR
Descriptor:E2 DARPin, Erythropoietin receptor, PHOSPHATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
<12>