5HVL

Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A

Summary for 5HVL

• Entry DOI: 10.2210/pdb5hvl/pdb
• Related: 5HUS 5HUT 5HUU 5HUV 5HVM 5HVO
• Descriptor: Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ... (5 entities in total)
• Functional Keywords: trehalose-6-phosphate synthase, transferase
• Biological source: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
• Total number of polymer chains: 2
• Total formula weight: 110713.49

Authors

Miao, Y.,Brennan, R.G. (deposition date: 2016-01-28, release date: 2017-05-03, Last modification date: 2024-04-03)

• Primary citation: Miao, Y.,Tenor, J.L.,Toffaletti, D.L.,Maskarinec, S.A.,Liu, J.,Lee, R.E.,Perfect, J.R.,Brennan, R.G.; Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.; MBio, 8:-, 2017; PubMed: 28743811; DOI: 10.1128/mBio.00643-17

Experimental method

X-RAY DIFFRACTION (1.796 Å)