5HVL
Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| A | 0004805 | molecular_function | trehalose-phosphatase activity |
| A | 0005575 | cellular_component | cellular_component |
| A | 0005946 | cellular_component | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005992 | biological_process | trehalose biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| A | 0030447 | biological_process | filamentous growth |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0036168 | biological_process | filamentous growth of a population of unicellular organisms in response to heat |
| A | 0036180 | biological_process | filamentous growth of a population of unicellular organisms in response to biotic stimulus |
| A | 0071465 | biological_process | cellular response to desiccation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| B | 0004805 | molecular_function | trehalose-phosphatase activity |
| B | 0005575 | cellular_component | cellular_component |
| B | 0005946 | cellular_component | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005992 | biological_process | trehalose biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016758 | molecular_function | hexosyltransferase activity |
| B | 0030447 | biological_process | filamentous growth |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0034605 | biological_process | cellular response to heat |
| B | 0036168 | biological_process | filamentous growth of a population of unicellular organisms in response to heat |
| B | 0036180 | biological_process | filamentous growth of a population of unicellular organisms in response to biotic stimulus |
| B | 0071465 | biological_process | cellular response to desiccation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue UDP A 501 |
| Chain | Residue |
| A | ARG280 |
| A | GLU387 |
| A | VDM502 |
| A | HOH635 |
| A | HOH640 |
| A | HOH723 |
| A | HOH729 |
| A | HOH765 |
| A | HOH782 |
| A | HOH793 |
| A | HOH859 |
| A | LYS285 |
| A | VAL315 |
| A | SER356 |
| A | ILE357 |
| A | LEU362 |
| A | ASN382 |
| A | LEU383 |
| A | VAL384 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue VDM A 502 |
| Chain | Residue |
| A | ASP143 |
| A | TYR144 |
| A | HIS145 |
| A | HIS171 |
| A | ILE242 |
| A | ARG280 |
| A | ARG318 |
| A | ASP379 |
| A | GLY380 |
| A | MET381 |
| A | ASN382 |
| A | UDP501 |
| A | HOH665 |
| A | HOH742 |
| A | HOH799 |
| A | HOH807 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | SER176 |
| A | SER177 |
| A | ARG208 |
| A | ARG208 |
| A | HIS209 |
| A | HIS209 |
| A | SER212 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue UDP B 501 |
| Chain | Residue |
| B | ARG280 |
| B | LYS285 |
| B | VAL315 |
| B | SER356 |
| B | ILE357 |
| B | LEU362 |
| B | ASN382 |
| B | LEU383 |
| B | VAL384 |
| B | GLU387 |
| B | VDM502 |
| B | HOH647 |
| B | HOH662 |
| B | HOH705 |
| B | HOH735 |
| B | HOH745 |
| B | HOH760 |
| B | HOH803 |
| B | HOH805 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue VDM B 502 |
| Chain | Residue |
| B | ASP143 |
| B | HIS145 |
| B | HIS171 |
| B | ILE242 |
| B | ARG280 |
| B | ARG318 |
| B | ASP379 |
| B | GLY380 |
| B | MET381 |
| B | ASN382 |
| B | UDP501 |
| B | HOH761 |
| B | HOH763 |
| B | HOH872 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | SER176 |
| B | SER177 |
| B | ARG208 |
| B | HIS209 |
| B | SER212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743811","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743811","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HUT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
