5HVL

Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
A	0004805	molecular_function	trehalose-phosphatase activity
A	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
A	0005975	biological_process	carbohydrate metabolic process
A	0005992	biological_process	trehalose biosynthetic process
A	0006623	biological_process	protein targeting to vacuole
A	0016757	molecular_function	glycosyltransferase activity
A	0016758	molecular_function	hexosyltransferase activity
A	0030447	biological_process	filamentous growth
A	0034605	biological_process	cellular response to heat
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0036168	biological_process	filamentous growth of a population of unicellular organisms in response to heat
A	0036180	biological_process	filamentous growth of a population of unicellular organisms in response to biotic stimulus
A	0070413	biological_process	trehalose metabolism in response to stress
A	0071465	biological_process	cellular response to desiccation
B	0003824	molecular_function	catalytic activity
B	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
B	0004805	molecular_function	trehalose-phosphatase activity
B	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
B	0005975	biological_process	carbohydrate metabolic process
B	0005992	biological_process	trehalose biosynthetic process
B	0006623	biological_process	protein targeting to vacuole
B	0016757	molecular_function	glycosyltransferase activity
B	0016758	molecular_function	hexosyltransferase activity
B	0030447	biological_process	filamentous growth
B	0034605	biological_process	cellular response to heat
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0036168	biological_process	filamentous growth of a population of unicellular organisms in response to heat
B	0036180	biological_process	filamentous growth of a population of unicellular organisms in response to biotic stimulus
B	0070413	biological_process	trehalose metabolism in response to stress
B	0071465	biological_process	cellular response to desiccation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue UDP A 501

Chain	Residue
A	ARG280
A	GLU387
A	VDM502
A	HOH635
A	HOH640
A	HOH723
A	HOH729
A	HOH765
A	HOH782
A	HOH793
A	HOH859
A	LYS285
A	VAL315
A	SER356
A	ILE357
A	LEU362
A	ASN382
A	LEU383
A	VAL384

---

site_id	AC2
Number of Residues	16
Details	binding site for residue VDM A 502

Chain	Residue
A	ASP143
A	TYR144
A	HIS145
A	HIS171
A	ILE242
A	ARG280
A	ARG318
A	ASP379
A	GLY380
A	MET381
A	ASN382
A	UDP501
A	HOH665
A	HOH742
A	HOH799
A	HOH807

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 503

Chain	Residue
A	SER176
A	SER177
A	ARG208
A	ARG208
A	HIS209
A	HIS209
A	SER212

---

site_id	AC4
Number of Residues	19
Details	binding site for residue UDP B 501

Chain	Residue
B	ARG280
B	LYS285
B	VAL315
B	SER356
B	ILE357
B	LEU362
B	ASN382
B	LEU383
B	VAL384
B	GLU387
B	VDM502
B	HOH647
B	HOH662
B	HOH705
B	HOH735
B	HOH745
B	HOH760
B	HOH803
B	HOH805

---

site_id	AC5
Number of Residues	14
Details	binding site for residue VDM B 502

Chain	Residue
B	ASP143
B	HIS145
B	HIS171
B	ILE242
B	ARG280
B	ARG318
B	ASP379
B	GLY380
B	MET381
B	ASN382
B	UDP501
B	HOH761
B	HOH763
B	HOH872

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 B 503

Chain	Residue
B	SER176
B	SER177
B	ARG208
B	HIS209
B	SER212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28743811, ECO:0007744|PDB:5HUU

Chain	Residue	Details
A	TYR89
A	ASP143
A	ARG318
A	LEU383
B	TYR89
B	ASP143
B	ARG318
B	LEU383

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28743811, ECO:0007744|PDB:5HUT

Chain	Residue	Details
A	ARG280
A	LYS285
A	ILE357
A	ASP379
B	ARG280
B	LYS285
B	ILE357
B	ASP379

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