5HUT

Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose

Summary for 5HUT

Entry DOI	10.2210/pdb5hut/pdb
Related	5HUS 5HUU 5HUV
Descriptor	Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE, SULFATE ION, ... (6 entities in total)
Functional Keywords	trehalose-6-phosphate synthase, transferase
Biological source	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Total number of polymer chains	2
Total formula weight	111942.54
Authors	Miao, Y.,Brennan, R.G. (deposition date: 2016-01-27, release date: 2017-05-03, Last modification date: 2024-04-03)
Primary citation	Miao, Y.,Tenor, J.L.,Toffaletti, D.L.,Maskarinec, S.A.,Liu, J.,Lee, R.E.,Perfect, J.R.,Brennan, R.G. Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8:-, 2017 Cited by PubMed: 28743811 DOI: 10.1128/mBio.00643-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation