Author results

1C9Q
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP
分子名称:APOPTOSIS INHIBITOR IAP HOMOLOG, ZINC ION
著者Meadows, R.P., Fesik, S.W.
登録日1999-08-03
公開日2000-08-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Nature, 401, 1999
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
著者Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
登録日1996-03-22
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1SHC
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SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
著者Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J., Fesik, S.W.
登録日1996-03-27
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1A1W
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FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
分子名称:FADD PROTEIN
著者Eberstadt, M., Huang, B., Chen, Z., Meadows, R.P., Ng, C., Fesik, S.W.
登録日1997-12-18
公開日1998-12-30
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
1A1Z
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FADD DEATH EFFECTOR DOMAIN, F25G MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
分子名称:FADD PROTEIN
著者Eberstadt, M., Huang, B., Chen, Z., Meadows, R.P., Ng, C., Fesik, S.W.
登録日1997-12-18
公開日1998-12-30
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
1BC9
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CYTOHESIN-1/B2-1 SEC7 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:CYTOHESIN-1
著者Betz, S.F., Schnuchel, A., Wang, H., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
登録日1998-05-06
公開日1999-05-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BVH
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SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
分子名称:ACID PHOSPHATASE
著者Logan, T.M., Zhou, M.-M., Nettesheim, D.G., Meadows, R.P., Van Etten, R.L., Fesik, S.W.
登録日1994-05-03
公開日1994-07-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
1BXL
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STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:BCL-XL, BAK PEPTIDE
著者Sattler, M., Liang, H., Nettesheim, D., Meadows, R.P., Harlan, J.E., Eberstadt, M., Yoon, H., Shuker, S.B., Chang, B.S., Minn, A.J., Thompson, C.B., Fesik, S.W.
登録日1996-10-16
公開日1997-10-29
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
1DDF
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FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:FAS
著者Huang, B., Eberstadt, M., Olejniczak, E., Meadows, R.P., Fesik, S.
登録日1996-11-08
公開日1997-11-12
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
Nature, 384, 1996
1DHM
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DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:E2 PROTEIN
著者Liang, H., Petros, A.P., Meadows, R.P., Yoon, H.S., Egan, D.A., Walter, K., Holzman, T.F., Robins, T., Fesik, S.W.
登録日1995-08-15
公開日1996-12-07
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions.
Biochemistry, 35, 1996
1F9X
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP
分子名称:INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION
著者Sun, C., Cai, M., Meadows, R.P., Fesik, S.W.
登録日2000-07-11
公開日2001-07-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
1FLI
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DNA-BINDING DOMAIN OF FLI-1
分子名称:FLI-1
著者Liang, H., Mao, X., Olejniczak, E.T., Nettesheim, D.G., Yu, L., Meadows, R.P., Thompson, C.B., Fesik, S.W.
登録日1994-09-15
公開日1995-09-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the ets domain of Fli-1 when bound to DNA.
Nat.Struct.Biol., 1, 1994
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
著者Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
登録日2000-10-24
公開日2001-01-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1G5J
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COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD
分子名称:APOPTOSIS REGULATOR BCL-X, BAD PROTEIN
著者Petros, A.M., Nettesheim, D.G., Wang, Y., Olejniczak, E.T., Meadows, R.P., Mack, J., Swift, K., Matayoshi, E.D., Zhang, H., Thompson, C.B., Fesik, S.W.
登録日2000-11-01
公開日2001-02-07
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein Sci., 9, 2000
1LXL
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NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
分子名称:BCL-XL
著者Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
登録日1996-04-04
公開日1997-04-21
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1MAZ
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X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH
分子名称:Bcl-2-like protein 1
著者Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.L., Ng, S.C., Fesik, S.W.
登録日1996-04-09
公開日1997-04-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Nature, 381, 1996
1PLS
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SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN
分子名称:PLECKSTRIN HOMOLOGY DOMAIN
著者Yoon, H.S., Hajduk, P.J., Petros, A.M., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
登録日1994-05-03
公開日1995-06-03
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of a pleckstrin-homology domain.
Nature, 369, 1994
1RRI
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DHNA COMPLEX WITH 3-(5-AMINO-7-HYDROXY-[1,2,3] TRIAZOLO [4,5-D]PYRIMIDIN-2-YL)-BENZOIC ACID
分子名称:Dihydroneopterin aldolase, 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-BENZOIC ACID
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-08
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RRW
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DHNA COMPLEXED WITH 9-METHYLGUANINE
分子名称:Dihydroneopterin aldolase, 9-METHYLGUANINE
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RRY
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DHNA COMPLEXED WITH 2-AMINO-4-HYDROXY-5-CARBOXYETHYLPYRIMIDINE
分子名称:Dihydroneopterin aldolase, 2-AMINO-4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RS2
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DHNA COMPLEX WITH 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE
分子名称:Dihydroneopterin aldolase, 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RS4
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DHNA, 7,8-DIHYDRONEOPTERIN ALDOLASE COMPLEXED WITH 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-(3,5-DICHLOROBENZYL)-BENZAMIDE
分子名称:Dihydroneopterin aldolase, 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-(3,5-DICHLOROBENZYL)-BENZAMIDE
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RSD
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DHNA COMPLEX WITH 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-[2-(2-HYDROXYMETHYL-PHENYLSULFANYL)-BENZYL]-BENZAMIDE
分子名称:Dihydroneopterin aldolase, 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-[2-(2-(HYDROXYMETHYL-PHENYLSULFANYL)-BENZYL]-BENZAMIDE
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RSI
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DHNA COMPLEX WITH 2-AMINO-5-BROMO-3-HYDROXY-6-PHENYLPYRIMIDINE
分子名称:Dihydroneopterin aldolase, 2-AMINO-5-BROMO-6-PHENYLPYRIMIDIN-4-OL
著者Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1TCE
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SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
分子名称:SHC, PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR
著者Zhou, M.-M., Meadows, R.P., Logan, T.M., Yoon, H.S., Wade, W.R., Ravichandran, K.S., Burakoff, S.J., Feisk, S.W.
登録日1996-03-27
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
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