1FLI

DNA-BINDING DOMAIN OF FLI-1

Summary for 1FLI

Entry DOI	10.2210/pdb1fli/pdb
Descriptor	FLI-1 (1 entity in total)
Functional Keywords	transcription/dna, transcription-dna complex
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q01543
Total number of polymer chains	1
Total formula weight	11444.93
Authors	Liang, H.,Mao, X.,Olejniczak, E.T.,Nettesheim, D.G.,Yu, L.,Meadows, R.P.,Thompson, C.B.,Fesik, S.W. (deposition date: 1994-09-15, release date: 1995-09-15, Last modification date: 2024-05-22)
Primary citation	Liang, H.,Mao, X.,Olejniczak, E.T.,Nettesheim, D.G.,Yu, L.,Meadows, R.P.,Thompson, C.B.,Fesik, S.W. Solution structure of the ets domain of Fli-1 when bound to DNA. Nat.Struct.Biol., 1:871-875, 1994 Cited by PubMed Abstract: Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA. PubMed: 7773776 DOI: 10.1038/nsb1294-871 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation