Author results

1IKG
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MICHAELIS COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANYL-D-ALANINE
Authors:Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A.
Deposit date:2001-05-03
Release date:2002-09-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
1IKI
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COMPLEX OF STREPTOMYCES R61 DD-PEPTIDASE WITH THE PRODUCTS OF A SPECIFIC PEPTIDOGLYCAN SUBSTRATE FRAGMENT
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, GLYCYL-L-ALPHA-AMINO-EPSILON-PIMELYL-D-ALANINE, D-ALANINE
Authors:Mcdonough, M.A., Anderson, J.W., Silvaggi, N.R., Pratt, R.F., Knox, J.R., Kelly, J.A.
Deposit date:2001-05-03
Release date:2002-09-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.
J.Mol.Biol., 322, 2002
1CP9
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CRYSTAL STRUCTURE OF PENICILLIN G ACYLASE FROM THE BRO1 MUTANT STRAIN OF PROVIDENCIA RETTGERI
Descriptor:Penicillin G amidase, SULFATE ION, CALCIUM ION
Authors:McDonough, M.A., Klei, H.E., Kelly, J.A.
Deposit date:1999-06-12
Release date:1999-06-24
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of penicillin G acylase from the Bro1 mutant strain of Providencia rettgeri.
Protein Sci., 8, 1999
1NKG
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RHAMNOGALACTURONAN LYASE FROM ASPERGILLUS ACULEATUS
Descriptor:Rhamnogalacturonase B, CALCIUM ION, SULFATE ION
Authors:McDonough, M.A., Kadirvelraj, R., Harris, P., Poulsen, J.C., Larsen, S.
Deposit date:2003-01-03
Release date:2004-05-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.
Febs Lett., 565, 2004
1YCI
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH N-(CARBOXYCARBONYL)-D-PHENYLALANINE
Descriptor:Hypoxia-inducible factor 1 alpha inhibitor, FE (II) ION, SULFATE ION, ...
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2004-12-22
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective inhibition of factor inhibiting hypoxia-inducible factor
J.Am.Chem.Soc., 127, 2005
2G1M
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CELLULAR OXYGEN SENSING: CRYSTAL STRUCTURE OF HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (PHD2)
Descriptor:Egl nine homolog 1, FE (II) ION, N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:Mcdonough, M.A., Schofield, C.J.
Deposit date:2006-02-14
Release date:2006-06-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proc.Natl.Acad.Sci.Usa, 103, 2006
3ZSC
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CATALYTIC FUNCTION AND SUBSTRATE RECOGNITION OF THE PECTATE LYASE FROM THERMOTOGA MARITIMA
Descriptor:PECTATE TRISACCHARIDE-LYASE, GLYCEROL, PHOSPHATE ION, ...
Authors:McDonough, M.A., Thymark, M., Frisner, H., Hotchkiss, A., Sonksen, C., Bjornvad, M., Johansen, K.S., Larsen, S.
Deposit date:2011-06-24
Release date:2012-07-11
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Catalytic Function and Substrate Recognition of the Pectate Lyase from Thermotoga Maritima
To be Published
2ZGD
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ASN-HYDROXYLATION STABILISES THE ANKYRIN REPEAT DOMAIN FOLD
Descriptor:3 repeat synthetic ankyrin, CADMIUM ION, CHLORIDE ION
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2008-01-21
Release date:2008-02-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold
Mol Biosyst, 5, 2009
2ZGG
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ASN-HYDROXYLATION STABILISES THE ANKYRIN REPEAT DOMAIN FOLD
Descriptor:3 repeat synthetic ankyrin, CADMIUM ION, COBALT (II) ION
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2008-01-21
Release date:2008-02-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold
Mol Biosyst, 5, 2009
2ILM
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FACTOR INHIBITING HIF-1 ALPHA D201A MUTANT IN COMPLEX WITH FE(II), ALPHA-KETOGLUTARATE AND HIF-1 ALPHA 35MER
Descriptor:Hypoxia-inducible factor 1 alpha inhibitor, Hypoxia-inducible factor 1 alpha, FE (II) ION, ...
Authors:Mcdonough, M.A., Schofield, C.J.
Deposit date:2006-10-03
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
3D8C
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FACTOR INHIBITING HIF-1 ALPHA D201G MUTANT IN COMPLEX WITH ZN(II), ALPHA-KETOGLUTARATE AND HIF-1 ALPHA 19MER
Descriptor:Hypoxia-inducible factor 1 alpha inhibitor, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ...
Authors:McDonough, M.A., Chowdhury, R., Schofield, C.J.
Deposit date:2008-05-23
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
1HVB
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CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, 5-{3-(S)-(4-(R)-ACETYLAMINO-4-CARBOXY-BUTYRYLAMINO)-3-[1-(R)-(1-(R)-CARBOXY-ETHYLCARBAMOYL)-ETHYLCARBAMOYL]-PROPYL}-2-(CARBOXY-PHENYLACETYLAMINO-METHYL)-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
Authors:McDonough, M.A., Lee, W., Silvaggi, N.R., Mobashery, S., Kelly, J.A.
Deposit date:2001-01-08
Release date:2001-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.
Proc.Natl.Acad.Sci.USA, 98, 2001
2A1X
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HUMAN PHYTANOYL-COA 2-HYDROXYLASE IN COMPLEX WITH IRON AND 2-OXOGLUTARATE
Descriptor:Phytanoyl-CoA dioxygenase, FE (II) ION, 2-OXOGLUTARIC ACID
Authors:Kavanagh, K.L., McDonough, M.A., Searles, T., Butler, D., Bunkoczi, G., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-06-21
Release date:2005-08-16
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease
J.Biol.Chem., 280, 2005
2CGN
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FACTOR INHIBITING HIF-1 ALPHA WITH SUCCINATE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, SUCCINIC ACID, ...
Authors:McDonough, M.A., Clifton, I.J., Schofield, C.J.
Deposit date:2006-03-09
Release date:2006-12-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
J.Biol.Chem., 282, 2007
2CGO
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FACTOR INHIBITING HIF-1 ALPHA WITH FUMARATE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, FUMARIC ACID, ...
Authors:McDonough, M.A., Clifton, I.J., Schofield, C.J.
Deposit date:2006-03-09
Release date:2006-12-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
J.Biol.Chem., 282, 2007
2QC9
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MOUSE NOTCH 1 ANKYRIN REPEAT INTRACELLULAR DOMAIN
Descriptor:Notch 1 protein
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2007-06-19
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
J.Biol.Chem., 282, 2007
3P3N
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH NOTCH 1 FRAGMENT MOUSE NOTCH (1930-1949) PEPTIDE
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, Notch 1 protein, FE (II) ION, ...
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2010-10-05
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
J.Biol.Chem., 282, 2007
3P3P
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH NOTCH 1 FRAGMENT MOUSE NOTCH (1997-2016) PEPTIDE
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, Notch 1 protein, FE (II) ION, ...
Authors:McDonough, M.A., Schofield, C.J.
Deposit date:2010-10-05
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
J.Biol.Chem., 282, 2007
3UIW
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ZEBRAFISH GRX2 (APO)
Descriptor:Glutaredoxin 2, GLUTATHIONE, SULFATE ION
Authors:McDonough, M.A., Johansson, C.
Deposit date:2011-11-06
Release date:2013-03-27
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis
To be Published
4BP0
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CRYSTAL STRUCTURE OF THE CLOSED FORM OF PSEUDOMONAS AERUGINOSA SPM-1
Descriptor:METALLO-B-LACTAMASE, ZINC ION, GLYCEROL, ...
Authors:McDonough, M.A., Brem, J., Schofield, C.J.
Deposit date:2013-05-22
Release date:2014-06-18
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Studying the active-site loop movement of the Sao Paolo metallo-beta-lactamase-1
Chem Sci, 6, 2015
4CCL
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X-RAY STRUCTURE OF E. COLI YCFD
Descriptor:50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION
Authors:McDonough, M.A., Ho, C.H., Kershaw, N.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-04-30
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CSW
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE
Descriptor:CUPIN 4 FAMILY PROTEIN, CITRIC ACID, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-11
Release date:2014-04-09
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CUG
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE IN COMPLEX SUBSTRATE FRAGMENT
Descriptor:CUPIN 4 FAMILY PROTEIN, 50S RIBOSOMAL PROTEIN L16, MANGANESE (II) ION, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-18
Release date:2014-04-16
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CWD
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CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ...
Authors:McDonough, M.A., Kochan, G., Rydzik, A., Schofield, C.J.
Deposit date:2014-04-02
Release date:2014-09-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
Angew. Chem. Int. Ed. Engl., 53, 2014
4YR7
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STRUCTURE OF LUXP IN COMPLEX WITH 1-DEOXY-ALPHA-L-XYLULOFURANOSE-1,2-BORATE
Descriptor:Autoinducer 2-binding periplasmic protein LuxP, 1-deoxy-alpha-L-xylulofuranose-1,2-borate
Authors:McDonough, M.A., Sattin, S., Davis, B.G.
Deposit date:2015-03-14
Release date:2016-03-23
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.533 Å)
Cite:Discovery of Glycomimetic Agonists from a Protocell Metabolism, Proto-natural Product Libraries
To Be Published