6F0W

prolyl hydroxylase in complex with hypoxia inducible factor oxygen degradation domain peptide fragment from Trichoplax adhaerens

Summary for 6F0W

• Entry DOI: 10.2210/pdb6f0w/pdb
• Related: 6YE1
• Descriptor: HIF prolyl hydroxylase, Hypoxia inducible factor, alpha subunit, N-OXALYLGLYCINE, ... (5 entities in total)
• Functional Keywords: prolyl hydroxylase, oxygenase, oxidoreductase, oxygen sensing, hypoxia inducible factor
• Biological source: Trichoplax adhaerens (Trichoplax reptans); More
• Total number of polymer chains: 2
• Total formula weight: 31896.81

Authors

McDonough, M.A.,Boleininger, A.,Schofield, C.J. (deposition date: 2017-11-20, release date: 2018-10-03, Last modification date: 2024-11-20)

Primary citation

Lippl, K.,Boleininger, A.,McDonough, M.A.,Abboud, M.I.,Tarhonskaya, H.,Chowdhury, R.,Loenarz, C.,Schofield, C.J.
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens.
Hypoxia (Auckl), 6:57-71, 2018

PubMed Abstract: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia sensors for the HIF system in organisms ranging from humans to the simplest animal .

PubMed: 30519597
DOI: 10.2147/HP.S174655

Experimental method

X-RAY DIFFRACTION (1.301 Å)