6RK9

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and cyclic peptide substrate mimic of factor X

Replaces:  5JZZ

Summary for 6RK9

• Entry DOI: 10.2210/pdb6rk9/pdb
• Related: 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU
• Descriptor: Aspartyl/asparaginyl beta-hydroxylase, ACA-LYS-ASP-GLY-LEU-GLY-GLU-TYR-THR-CYS-THR-SER-LEU-GLU-GLY-PHE-GLU, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: 2-oxoglutarate dependent oxygenase, aspartyl/asparaginyl beta-hydroxylase, egf-like domain hydroxylase, double stranded beta-helix, tetratricopeptide repeat, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 101221.90

Authors

McDonough, M.A.,Pfeffer, I. (deposition date: 2019-04-30, release date: 2019-05-08, Last modification date: 2024-01-24)

• Primary citation: Pfeffer, I.,Brewitz, L.,Krojer, T.,Jensen, S.A.,Kochan, G.T.,Kershaw, N.J.,Hewitson, K.S.,McNeill, L.A.,Kramer, H.,Munzel, M.,Hopkinson, R.J.,Oppermann, U.,Handford, P.A.,McDonough, M.A.,Schofield, C.J.; Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.; Nat Commun, 10:4910-4910, 2019; PubMed: 31659163; DOI: 10.1038/s41467-019-12711-7

Experimental method

X-RAY DIFFRACTION (2.292 Å)