Author results

1BKC
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CATALYTIC DOMAIN OF TNF-ALPHA CONVERTING ENZYME (TACE)
Descriptor:TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
Authors:Maskos, K., Fernandez-Catalan, C., Bode, W.
Deposit date:1998-04-23
Release date:1999-06-22
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
Proc.Natl.Acad.Sci.USA, 95, 1998
1Q2L
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CRYSTAL STRUCTURE OF PITRILYSIN
Descriptor:Protease III, ZINC ION, PLATINUM (II) ION
Authors:Maskos, K., Jozic, D., Fernandez-Catalan, C.
Deposit date:2003-07-25
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of pitrilysin, the prototype of insulin-degrading enzymes
To be Published
2E2D
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FLEXIBILITY AND VARIABILITY OF TIMP BINDING: X-RAY STRUCTURE OF THE COMPLEX BETWEEN COLLAGENASE-3/MMP-13 AND TIMP-2
Descriptor:Matrix metallopeptidase 13, Metalloproteinase inhibitor 2, ZINC ION, ...
Authors:Maskos, K., Lang, R., Tschesche, H., Bode, W.
Deposit date:2006-11-11
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flexibility and Variability of TIMP Binding: X-ray Structure of the Complex Between Collagenase-3/MMP-13 and TIMP-2
J.Mol.Biol., 366, 2007
1UWY
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CRYSTAL STRUCTURE OF HUMAN CARBOXYPEPTIDASE M
Descriptor:CARBOXYPEPTIDASE M, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Maskos, K., Reverter, D., Bode, W.
Deposit date:2004-02-17
Release date:2004-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Carboxypeptidase M, a Membrane-Bound Enzyme that Regulates Peptide Hormone Activity
J.Mol.Biol., 338, 2004
1JAE
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STRUCTURE OF TENEBRIO MOLITOR LARVAL ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION
Authors:Strobl, S., Maskos, K., Betz, M., Wiegand, G., Huber, R., Gomis-Rueth, F.X., Frank, G., Glockshuber, R.
Deposit date:1997-09-30
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of yellow meal worm alpha-amylase at 1.64 A resolution.
J.Mol.Biol., 278, 1998
1GT9
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HIGH RESOLUTION CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE, KUMAMOLISIN (KSCP)
Descriptor:KUMAMOLYSIN, CALCIUM ION, SULFATE ION
Authors:Comellas-Bigler, M., Fuentes-Prior, P., Maskos, K., Huber, R., Oyama, H., Uchida, K., Dunn, B.M., Oda, K., Bode, W.
Deposit date:2002-01-14
Release date:2002-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:The 1.4 A Crystal Structure of Kumamolysin. A Thermostable Serine-Carboxyl-Type Proteinase
Structure, 10, 2002
1GTG
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CRYSTAL STRUCTURE OF THE THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE, KUMAMOLYSIN (KSCP)
Descriptor:KUMAMOLYSIN, CALCIUM ION
Authors:Comellas-Bigler, M., Fuentes-Prior, P., Maskos, K., Huber, R., Oyama, H., Uchida, K., Dunn, B.M., Oda, K., Bode, W.
Deposit date:2002-01-15
Release date:2002-06-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The 1.4 A Crystal Structure of Kumamolysin. A Thermostable Serine-Carboxyl-Type Proteinase
Structure, 10, 2002
1GTJ
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CRYSTAL STRUCTURE OF THE THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE, KUMAMOLISIN (KSCP) - COMPLEX WITH AC-ILE-ALA-PHE-CHO
Descriptor:KUMAMOLYSIN, ALDEHYDE INHIBITOR, SULFATE ION, ...
Authors:Comellas-Bigler, M., Fuentes-Prior, P., Maskos, K., Huber, R., Oyama, H., Uchida, K., Dunn, B.M., Oda, K., Bode, W.
Deposit date:2002-01-15
Release date:2002-06-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The 1.4 A Crystal Structure of Kumamolysin. A Thermostable Serine-Carboxyl-Type Proteinase
Structure, 10, 2002
1GTL
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THE THERMOSTABLE SERINE-CARBOXYL TYPE PROTEINASE, KUMAMOLISIN (KSCP) - COMPLEX WITH AC-ILE-PRO-PHE-CHO
Descriptor:KUMAMOLYSIN, ALDEHYDE INHIBITOR, CALCIUM ION, ...
Authors:Comellas-Bigler, M., Fuentes-Prior, P., Maskos, K., Huber, R., Oyama, H., Uchida, K., Dunn, B.M., Oda, K., Bode, W.
Deposit date:2002-01-16
Release date:2002-06-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The 1.4 A Crystal Structure of Kumamolysin. A Thermostable Serine-Carboxyl-Type Proteinase
Structure, 10, 2002
1UEA
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MMP-3/TIMP-1 COMPLEX
Descriptor:MATRIX METALLOPROTEINASE-3, TISSUE INHIBITOR OF METALLOPROTEINASE-1, ZINC ION, ...
Authors:Bode, W., Maskos, K., Gomis-Rueth, F.-X., Nagase, H.
Deposit date:1997-06-06
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature, 389, 1997
1T1E
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE INTACT PRO-KUMAMOLISIN, A SEDOLISIN TYPE PROTEINASE (PREVIOUSLY CALLED KUMAMOLYSIN OR KSCP)
Descriptor:kumamolisin, CALCIUM ION
Authors:Comellas-Bigler, M., Maskos, K., Huber, R., Oyama, H., Oda, K., Bode, W.
Deposit date:2004-04-16
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:1.2 a crystal structure of the serine carboxyl proteinase pro-kumamolisin: structure of an intact pro-subtilase
Structure, 12, 2004
1T1G
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HIGH RESOLUTION CRYSTAL STRUCTURE OF MUTANT E23A OF KUMAMOLISIN, A SEDOLISIN TYPE PROTEINASE (PREVIOUSLY CALLED KUMAMOLYSIN OR KSCP)
Descriptor:kumamolisin, CALCIUM ION, SULFATE ION
Authors:Comellas-Bigler, M., Maskos, K., Huber, R., Oyama, H., Oda, K., Bode, W.
Deposit date:2004-04-16
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:1.2 a crystal structure of the serine carboxyl proteinase pro-kumamolisin: structure of an intact pro-subtilase
Structure, 12, 2004
1T1I
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HIGH RESOLUTION CRYSTAL STRUCTURE OF MUTANT W129A OF KUMAMOLISIN, A SEDOLISIN TYPE PROTEINASE (PREVIOUSLY CALLED KUMAMOLYSIN OR KSCP)
Descriptor:kumamolisin, CALCIUM ION, SULFATE ION
Authors:Comellas-Bigler, M., Maskos, K., Huber, R., Oyama, H., Oda, K., Bode, W.
Deposit date:2004-04-16
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:1.2 a crystal structure of the serine carboxyl proteinase pro-kumamolisin: structure of an intact pro-subtilase
Structure, 12, 2004
3LU6
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HUMAN SERUM ALBUMIN IN COMPLEX WITH COMPOUND 1
Descriptor:Serum albumin, [(1R,2R)-2-{[(5-fluoro-1H-indol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl]acetic acid
Authors:Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.
Deposit date:2010-02-17
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions
Bioorg.Med.Chem., 18, 2010
3LU7
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HUMAN SERUM ALBUMIN IN COMPLEX WITH COMPOUND 2
Descriptor:Serum albumin, 4-[(1R,2R)-2-{[(5-fluoro-1H-indol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl]butanoic acid, PHOSPHATE ION
Authors:Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.
Deposit date:2010-02-17
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions
Bioorg.Med.Chem., 18, 2010
3LU8
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HUMAN SERUM ALBUMIN IN COMPLEX WITH COMPOUND 3
Descriptor:Serum albumin, N-[5-(5-{[(2,4-dimethyl-1,3-thiazol-5-yl)sulfonyl]amino}-6-fluoropyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide
Authors:Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.
Deposit date:2010-02-17
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions
Bioorg.Med.Chem., 18, 2010
5HVY
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CDK8/CYCC IN COMPLEX WITH COMPOUND 20
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, N-{(3S)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-N'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}urea, ...
Authors:Kiefer, J.R., Schneider, E.V., Maskos, K., Bergeron, P., Koehler, M.
Deposit date:2016-01-28
Release date:2016-04-20
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.
Acs Med.Chem.Lett., 7, 2016
3C7X
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HEMOPEXIN-LIKE DOMAIN OF MATRIX METALLOPROTEINASE 14
Descriptor:Matrix metalloproteinase-14, SODIUM ION, CHLORIDE ION
Authors:Tochowicz, A., Itoh, Y., Maskos, K., Bode, W., Goettig, P.
Deposit date:2008-02-08
Release date:2009-02-10
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions
J.Biol.Chem., 286, 2011
5CEI
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CRYSTAL STRUCTURE OF CDK8:CYCLIN C COMPLEX WITH COMPOUND 22
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, 1,2-ETHANEDIOL, ...
Authors:Kiefer, J.R., Schneider, E.V., Maskos, K., Koehler, M.F.T.
Deposit date:2015-07-06
Release date:2016-02-10
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
Acs Med.Chem.Lett., 7, 2016
1BQQ
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CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX
Descriptor:MEMBRANE-TYPE MATRIX METALLOPROTEINASE, METALLOPROTEINASE INHIBITOR 2, CALCIUM ION, ...
Authors:Fernandez-Catalan, C., Bode, W., Huber, R., Turk, D., Calvete, J.J., Lichte, A., Tschesche, H., Maskos, K.
Deposit date:1998-08-18
Release date:1999-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
EMBO J., 17, 1998
1BUV
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CRYSTAL STRUCTURE OF THE MT1-MMP-TIMP-2 COMPLEX
Descriptor:PROTEIN (MEMBRANE-TYPE MATRIX METALLOPROTEINASE (CDMT1-MMP)), PROTEIN (METALLOPROTEINASE INHIBITOR (TIMP-2)), CALCIUM ION, ...
Authors:Fernandez-Catalan, C., Bode, W., Huber, R., Turk, D., Calvete, J.J., Lichte, A., Tschesche, H., Maskos, K.
Deposit date:1998-09-07
Release date:1999-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
EMBO J., 17, 1998
1JK3
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CRYSTAL STRUCTURE OF HUMAN MMP-12 (MACROPHAGE ELASTASE) AT TRUE ATOMIC RESOLUTION
Descriptor:MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ...
Authors:Lang, R., Kocourek, A., Braun, M., Tschesche, H., Huber, R., Bode, W., Maskos, K.
Deposit date:2001-07-11
Release date:2001-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
J.Mol.Biol., 312, 2001
1LFW
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CRYSTAL STRUCTURE OF PEPV
Descriptor:pepV, ZINC ION, 3-[(1-AMINO-2-CARBOXY-ETHYL)-HYDROXY-PHOSPHINOYL]-2-METHYL-PROPIONIC ACID
Authors:Jozic, D., Bourenkow, G., Bartunik, H., Scholze, H., Dive, V., Henrich, B., Huber, R., Bode, W., Maskos, K.
Deposit date:2002-04-12
Release date:2002-10-23
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Dinuclear Zinc Aminopeptidase PepV from Lactobacillus delbrueckii Unravels Its Preference for Dipeptides
Structure, 10, 2002
1PO9
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CRYTSAL STRUCTURE OF ISOASPARTYL DIPEPTIDASE
Descriptor:Isoaspartyl dipeptidase, ZINC ION
Authors:Jozic, D., Kaiser, J.T., Huber, R., Bode, W., Maskos, K.
Deposit date:2003-06-15
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases.
J.Mol.Biol., 332, 2003
1POJ
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ISOASPARTYL DIPEPTIDASE WITH BOUND INHIBITOR
Descriptor:Isoaspartyl dipeptidase, ZINC ION, 2-{[[(1S)-1-AMINO-2-CARBOXYETHYL](DIHYDROXY)PHOSPHORANYL]METHYL}-4-METHYLPENTANOIC ACID
Authors:Jozic, D., Kaiser, J.T., Huber, R., Bode, W., Maskos, K.
Deposit date:2003-06-15
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases.
J.Mol.Biol., 332, 2003