3LU7

Human serum albumin in complex with compound 2

Summary for 3LU7

Related3LU6 3LU8
DescriptorSerum albumin, 4-[(1R,2R)-2-{[(5-fluoro-1H-indol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl]butanoic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordsbinding sites, ligands, protein binding, serum albumin, hsa, proteros biostructures gmbh, transport protein, astrazeneca, drug design
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02768
Total number of polymer chains2
Total molecular weight134378.12
Authors
Buttar, D.,Colclough, N.,Gerhardt, S.,MacFaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H. (deposition date: 2010-02-17, release date: 2010-10-27, Last modification date: 2011-07-13)
Primary citation
Buttar, D.,Colclough, N.,Gerhardt, S.,Macfaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H.
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions
Bioorg.Med.Chem., 18:7486-7496, 2010
PubMed: 20869876 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2010.08.052
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27681.6%3.8%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution