3LU8

Human serum albumin in complex with compound 3

Summary for 3LU8

• Entry DOI: 10.2210/pdb3lu8/pdb
• Related: 3LU6 3LU7
• Descriptor: Serum albumin, N-[5-(5-{[(2,4-dimethyl-1,3-thiazol-5-yl)sulfonyl]amino}-6-fluoropyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide (3 entities in total)
• Functional Keywords: binding sites, ligands, protein binding, serum albumin, hsa, proteros biostructures gmbh, transport protein, astrazeneca, drug design
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02768
• Total number of polymer chains: 2
• Total formula weight: 134025.48

Authors

Buttar, D.,Colclough, N.,Gerhardt, S.,MacFaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H. (deposition date: 2010-02-17, release date: 2010-10-27, Last modification date: 2011-07-13)

• Primary citation: Buttar, D.,Colclough, N.,Gerhardt, S.,Macfaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H.; A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions; Bioorg.Med.Chem., 18:7486-7496, 2010; PubMed: 20869876; DOI: 10.1016/j.bmc.2010.08.052

Experimental method

X-RAY DIFFRACTION (2.6 Å)