6R5Z
 
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6R5X
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6R5Y
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1L6S
 | | Crystal Structure of Porphobilinogen Synthase Complexed with the Inhibitor 4,7-Dioxosebacic Acid | | Descriptor: | 4,7-DIOXOSEBACIC ACID, MAGNESIUM ION, PORPHOBILINOGEN SYNTHASE, ... | | Authors: | Jaffe, E.K, Kervinen, J, Martins, J, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A. | | Deposit date: | 2002-03-13 | | Release date: | 2002-04-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Species-Specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
J.Biol.Chem., 277, 2002
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1L6Y
 | | Crystal Structure of Porphobilinogen Synthase Complexed with the Inhibitor 4-Oxosebacic Acid | | Descriptor: | 4-OXODECANEDIOIC ACID, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Jaffe, E.K, Kervinen, J, Martins, J, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A. | | Deposit date: | 2002-03-14 | | Release date: | 2002-04-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Species-Specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
J.Biol.Chem., 277, 2002
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1UNC
 | | Solution structure of the human villin C-terminal headpiece subdomain | | Descriptor: | VILLIN 1 | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
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1UND
 | | Solution structure of the human advillin C-terminal headpiece subdomain | | Descriptor: | ADVILLIN | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
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6TM0
 | | N-Domain P40/P90 Mycoplasma pneumoniae complexed with 6'SL | | Descriptor: | Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Vizarraga, D, Aparicio, D, Illanes, R, Fita, I, Perez-Luque, R, Martin, J. | | Deposit date: | 2019-12-03 | | Release date: | 2020-11-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.
Nat Commun, 11, 2020
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4V0B
 | | Escherichia coli FtsH hexameric N-domain | | Descriptor: | ATP-DEPENDENT ZINC METALLOPROTEASE FTSH, SULFATE ION | | Authors: | Serek-Heuberger, J, Martin, J, Lupas, A.N, Hartmann, M.D. | | Deposit date: | 2014-09-13 | | Release date: | 2015-01-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure and Evolution of N-Domains in Aaa Metalloproteases.
J.Mol.Biol., 427, 2015
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8RXR
 | | Crystal structure of VPS34 in complex with inhibitor SB02024 | | Descriptor: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | | Deposit date: | 2024-02-07 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol, 2024
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6TLZ
 | | N-Domain P40/P90 Mycoplasma pneumoniae complexed with 3'SL | | Descriptor: | Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... | | Authors: | Vizarraga, D, Aparicio, D, Illanes, R, Fita, I, Perez-Luque, R, Martin, J. | | Deposit date: | 2019-12-03 | | Release date: | 2020-11-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.
Nat Commun, 11, 2020
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6ETJ
 | | HUMAN PFKFB3 IN COMPLEX WITH KAN0438241 | | Descriptor: | 4-[[3-(5-fluoranyl-2-oxidanyl-phenyl)phenyl]sulfonylamino]-2-oxidanyl-benzoic acid, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | | Authors: | Gustafsson, N.M.S, Lundback, T, Farnegardh, K, Groth, P, Wiitta, E, Jonsson, M, Hallberg, K, Pennisi, R, Huguet Ninou, A, Martinsson, J, Norstrom, C, Schultz, J, Andersson, M, Markova, N, Marttila, P, Norin, M, Olin, T, Helleday, T. | | Deposit date: | 2017-10-26 | | Release date: | 2018-11-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun, 9, 2018
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5OVS
 | | Thiobacillus denitrificans BPH | | Descriptor: | BPH | | Authors: | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | Deposit date: | 2017-08-29 | | Release date: | 2017-12-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
J. Biol. Chem., 293, 2018
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5OVU
 | | Cupriavidus metallidurans BPH | | Descriptor: | BETA-PROTEOBACTERIA PROTEASOME HOMOLOGUE, MALONATE ION | | Authors: | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | Deposit date: | 2017-08-29 | | Release date: | 2017-12-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
J. Biol. Chem., 293, 2018
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5OVT
 | | Thiobacillus denitrificans BPH in complex with Epoxomicin | | Descriptor: | BPH, Epoxomicin, PHOSPHATE ION | | Authors: | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | Deposit date: | 2017-08-29 | | Release date: | 2017-12-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
J. Biol. Chem., 293, 2018
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2VBU
 | | Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with CDP | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hartmann, M.D, Ammelburg, M, Djuranovic, S, Martin, J, Lupas, A.N, Zeth, K. | | Deposit date: | 2007-09-16 | | Release date: | 2007-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A Ctp-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels.
Structure, 15, 2007
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5LOX
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2VBV
 | | Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with CDP and FMN | | Descriptor: | CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Hartmann, M.D, Ammelburg, M, Djuranovic, S, Martin, J, Lupas, A.N, Zeth, K. | | Deposit date: | 2007-09-16 | | Release date: | 2007-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A Ctp-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels.
Structure, 15, 2007
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2VBS
 | | Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with PO4 | | Descriptor: | CHLORIDE ION, PHOSPHATE ION, RIBOFLAVIN KINASE, ... | | Authors: | Hartmann, M.D, Djuranovic, S, Ammelburg, M, Martin, J, Lupas, A.N, Zeth, K. | | Deposit date: | 2007-09-16 | | Release date: | 2007-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A Ctp-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels.
Structure, 15, 2007
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5LOY
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2VBT
 | | Riboflavin kinase Mj0056 from Methanocaldococcus jannaschii in complex with CDP and PO4 | | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, PHOSPHATE ION, RIBOFLAVIN KINASE, ... | | Authors: | Hartmann, M.D, Ammelburg, M, Djuranovic, S, Martin, J, Lupas, A.N, Zeth, K. | | Deposit date: | 2007-09-16 | | Release date: | 2007-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A Ctp-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels.
Structure, 15, 2007
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5LOS
 | | Piriformospora indica PIIN_05872 | | Descriptor: | PIIN_05872, SULFATE ION, ZINC ION | | Authors: | Hartmann, M.D, Albrecht, R, Martin, J, Lupas, A.N. | | Deposit date: | 2016-08-09 | | Release date: | 2018-05-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A secreted fungal histidine- and alanine-rich protein regulates metal ion homeostasis and oxidative stress.
New Phytol., 227, 2020
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2WFW
 | | Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases - The Arc domain structure | | Descriptor: | ARC | | Authors: | Djuranovic, S, Hartmann, M.D, Habeck, M, Ursinus, A, Zwickl, P, Martin, J, Lupas, A.N, Zeth, K. | | Deposit date: | 2009-04-15 | | Release date: | 2009-05-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure and Activity of the N-Terminal Substrate Recognition Domains in Proteasomal Atpases.
Mol.Cell, 34, 2009
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2MUY
 | | The solution structure of the FtsH periplasmic N-domain | | Descriptor: | ATP-dependent zinc metalloprotease FtsH | | Authors: | Scharfenberg, F, Serek-Heuberger, J, Martin, J, Lupas, A.N, Coles, M. | | Deposit date: | 2014-09-18 | | Release date: | 2015-01-28 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure and Evolution of N-domains in AAA Metalloproteases.
J.Mol.Biol., 427, 2015
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2MV3
 | | The N-domain of the AAA metalloproteinase Yme1 from Saccharomyces cerevisiae | | Descriptor: | Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 | | Authors: | Scharfenberg, F, Serek-Heuberger, J, Martin, J, Lupas, A.N, Coles, M. | | Deposit date: | 2014-09-22 | | Release date: | 2015-01-28 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure and Evolution of N-domains in AAA Metalloproteases.
J.Mol.Biol., 427, 2015
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