6ETJ

HUMAN PFKFB3 IN COMPLEX WITH KAN0438241

Summary for 6ETJ

Entry DOI	10.2210/pdb6etj/pdb
Descriptor	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, DIMETHYL SULFOXIDE, 6-O-phosphono-beta-D-fructofuranose, ... (6 entities in total)
Functional Keywords	dna damage repair, homologous recombination, glycolysis, nucleotide metabolism, pfkfb3, antitumor protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	60941.96
Authors	Gustafsson, N.M.S.,Lundback, T.,Farnegardh, K.,Groth, P.,Wiitta, E.,Jonsson, M.,Hallberg, K.,Pennisi, R.,Huguet Ninou, A.,Martinsson, J.,Norstrom, C.,Schultz, J.,Andersson, M.,Markova, N.,Marttila, P.,Norin, M.,Olin, T.,Helleday, T. (deposition date: 2017-10-26, release date: 2018-11-07, Last modification date: 2020-07-29)
Primary citation	Gustafsson, N.M.S.,Farnegardh, K.,Bonagas, N.,Ninou, A.H.,Groth, P.,Wiita, E.,Jonsson, M.,Hallberg, K.,Lehto, J.,Pennisi, R.,Martinsson, J.,Norstrom, C.,Hollers, J.,Schultz, J.,Andersson, M.,Markova, N.,Marttila, P.,Kim, B.,Norin, M.,Olin, T.,Helleday, T. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun, 9:3872-3872, 2018 Cited by PubMed: 30250201 DOI: 10.1038/s41467-018-06287-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation