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3NZJ
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2A
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-16
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH 2B
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2C
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
4JSQ
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:4E
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
J.Med.Chem., 56, 2013
4JSU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:3A
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
J.Med.Chem., 56, 2013
4JT0
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:4A
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Dimerized Linear Mimics of a Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome
J.Med.Chem., 2013
4GSF
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THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER
Descriptor:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
4QIA
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INHIBITOR N-BENZYL-N-(CARBOXYMETHYL)GLYCYL-L-HISTIDINE
Descriptor:Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2014-05-30
Release date:2015-05-13
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
2YPU
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HUMAN INSULIN DEGRADING ENZYME E111Q IN COMPLEX WITH INHIBITOR COMPOUND 41367
Descriptor:INSULIN-DEGRADING ENZYME, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.-J.
Deposit date:2012-11-01
Release date:2012-11-28
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C, 2014
3QZ2
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THE STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme, ZINC ION
Authors:Guo, Q., Tang, W.J.
Deposit date:2011-03-04
Release date:2012-01-25
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DTT
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPUND 41367
Descriptor:Insulin-degrading enzyme, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-02-21
Release date:2013-02-27
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DWK
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STRUCTURE OF CYSTEIN FREE INSULIN DEGRADING ENZYME WITH COMPOUND BDM41671 ((S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPYL)-AMINO]-ACETYLAMINO}-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
Descriptor:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-02-24
Release date:2013-04-03
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GS8
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STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH COMPOUND BDM43079 [{[(S)-2-(1H-IMIDAZOL-4-YL)-1-METHYLCARBAMOYL-ETHYLCARBAMOYL]-METHYL}-(3-PHENYL-PROPYL)-AMINO]-ACETIC ACID
Descriptor:Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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STRUCTURE ANALYSIS OF INSULIN DEGRADING ENZYME WITH COMPOUND BDM41559 ((S)-2-[2-(CARBOXYMETHYL-PHENETHYL-AMINO)-ACETYLAMINO]-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
Descriptor:Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
Authors:Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4IFH
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND BDM44619
Descriptor:Insulin-degrading enzyme, ZINC ION, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide
Authors:Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
Deposit date:2012-12-14
Release date:2013-12-18
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (3.286 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4NXO
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH BDM44768
Descriptor:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, ...
Authors:Liang, W.G., Deprez, R., Deprez, B., Tang, W.
Deposit date:2013-12-09
Release date:2015-10-07
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4RE9
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND 71290
Descriptor:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ...
Authors:Liang, W.G., Deprez, R., Deprez, B., Tang, W.J.
Deposit date:2014-09-22
Release date:2015-09-30
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015