4JSU

Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:3a

Summary for 4JSU

Related1RYP 1JD2 4JSQ 4JT0
Related PRD IDPRD_001044
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (17 entities in total)
Functional Keywordsups, proteasome, drug discovery, non-covalent reversible inhibition, bivalence, tmc-95a derivatives, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains32
Total molecular weight733287.75
Authors
Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. (deposition date: 2013-03-22, release date: 2013-05-01, Last modification date: 2014-04-23)
Primary citation
Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M.
Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
J.Med.Chem., 56:3367-3378, 2013
PubMed: 23540790 (PDB entries with the same primary citation)
DOI: 10.1021/jm4002007
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23350.4%3.3%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4jsu
no rotation
Molmil generated image of 4jsu
rotated about x axis by 90°
Molmil generated image of 4jsu
rotated about y axis by 90°