2VZ8 | |
2VZ9 | |
1O7A | | HUMAN BETA-HEXOSAMINIDASE B | | Descriptor: | BETA-HEXOSAMINIDASE BETA CHAIN, 2-ACETAMIDO-2-DEOXY-D-GLUCONO-1,5-LACTONE, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Maier, T., Strater, N., Schuette, C., Klingenstein, R., Sandhoff, K., Saenger, W. | | Deposit date: | 2002-10-29 | | Release date: | 2003-10-23 | | Last modified: | 2019-10-09 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The X-Ray Crystal Structure of Human Beta-Hexosaminidase B Provides New Insights Into Sandhoff Disease
J.Mol.Biol., 328, 2003
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2BJ6 | | CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID | | Descriptor: | SYNTHETIC HNA, 5'-R(*GP*GP*CP*AP*UP*UP*AP*CP*GP*GP)-3', SULFATE ION | | Authors: | Maier, T., Przylas, I., Straeter, N., Herdewijn, P., Saenger, W. | | Deposit date: | 2005-01-30 | | Release date: | 2005-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Reinforced Hna Backbone Hydration in the Crystal Structure of a Decameric Hna/RNA Hybrid
J.Am.Chem.Soc., 127, 2005
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2CF2 | | ARCHITECTURE OF MAMMALIAN FATTY ACID SYNTHASE | | Descriptor: | FATTY ACID SYNTHASE, KS DOMAIN, MAT DOMAIN, ... | | Authors: | Maier, T., Jenni, S., Ban, N. | | Deposit date: | 2006-02-14 | | Release date: | 2006-03-07 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | Architecture of Mammalian Fatty Acid Synthase at 4.5 A Resolution.
Science, 311, 2006
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4QKY | | CRYSTAL STRUCTURE ANALYSIS OF THE MEMBRANE TRANSPORTER FHAC | | Descriptor: | Filamentous hemagglutinin transporter protein FhaC, PHOSPHATE ION | | Authors: | Maier, T., Clantin, B., Gruss, F., Dewitte, F., Delattre, A.S., Jacob-Dubuisson, F., Hiller, S., Villeret, V. | | Deposit date: | 2014-06-10 | | Release date: | 2014-10-22 | | Last modified: | 2016-12-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Conserved Omp85 lid-lock structure and substrate recognition in FhaC
Nat Commun, 6, 2015
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4QL0 | | CRYSTAL STRUCTURE ANALYSIS OF THE MEMBRANE TRANSPORTER FHAC (DOUBLE MUTANT V169T, I176N) | | Descriptor: | Filamentous hemagglutinin transporter protein FhaC, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Maier, T., Clantin, B., Gruss, F., Dewitte, F., Delattre, A.S., Jacob-Dubuisson, F., Hiller, S., Villeret, V. | | Deposit date: | 2014-06-10 | | Release date: | 2015-06-17 | | Last modified: | 2016-12-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Conserved Omp85 lid-lock structure and substrate recognition in FhaC
Nat Commun, 6, 2015
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2R1Q | |
2RB3 | | CRYSTAL STRUCTURE OF HUMAN SAPOSIN D | | Descriptor: | Proactivator polypeptide, SULFATE ION, GLYCEROL | | Authors: | Maier, T., Rossman, M., Saenger, W. | | Deposit date: | 2007-09-18 | | Release date: | 2008-04-29 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.
Structure, 16, 2008
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3MEY | | CRYSTAL STRUCTURE OF CLASS II AARS HOMOLOGUE (BLL0957) COMPLEXED WITH ATP | | Descriptor: | Bll0957 protein, ZINC ION, MAGNESIUM ION, ... | | Authors: | Weygand-Durasevic, I., Mocibob, M., Ivic, N., Bilokapic, S., Maier, T., Luic, M., Ban, N. | | Deposit date: | 2010-04-01 | | Release date: | 2010-07-28 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis
Proc.Natl.Acad.Sci.USA, 107, 2010
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3MF1 | | CRYSTAL STRUCTURE OF CLASS II AARS HOMOLOGUE (BLL0957) COMPLEXED WITH AN ANALOGUE OF GLYCYL ADENYLATE | | Descriptor: | Bll0957 protein, ZINC ION, 5'-O-(glycylsulfamoyl)adenosine | | Authors: | Weygand-Durasevic, I., Mocibob, M., Ivic, N., Bilokapic, S., Maier, T., Luic, M., Ban, N. | | Deposit date: | 2010-04-01 | | Release date: | 2010-07-28 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis
Proc.Natl.Acad.Sci.USA, 107, 2010
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3MF2 | | CRYSTAL STRUCTURE OF CLASS II AARS HOMOLOGUE (BLL0957) COMPLEXED WITH AMP | | Descriptor: | Bll0957 protein, ZINC ION, ADENOSINE MONOPHOSPHATE, ... | | Authors: | Weygand-Durasevic, I., Mocibob, M., Ivic, N., Bilokapic, S., Maier, T., Luic, M., Ban, N. | | Deposit date: | 2010-04-01 | | Release date: | 2010-07-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis
Proc.Natl.Acad.Sci.USA, 107, 2010
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5L4V | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 3-DEOXY-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 3-Deoxy-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, T. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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4CSS | | CRYSTAL STRUCTURE OF FIMH IN COMPLEX WITH A SULFONAMIDE BIPHENYL ALPHA D-MANNOSIDE | | Descriptor: | PROTEIN FIMH, 4'-(alpha-D-Mannopyranosyloxy)-biphenyl-4-methyl sulfonamide, GLYCEROL | | Authors: | Kleeb, S., Pang, L., Mayer, K., Sigl, A., Eris, D., Preston, R.C., Zihlmann, P., Abgottspon, D., Hutter, A., Scharenberg, M., Jian, X., Navarra, G., Rabbani, S., Smiesko, M., Luedin, N., Jakob, R.P., Schwardt, O., Maier, T., Sharpe, T., Ernst, B. | | Deposit date: | 2014-03-10 | | Release date: | 2015-02-25 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (1.069 Å) | | Cite: | Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile.
J.Med.Chem., 58, 2015
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4CST | | CRYSTAL STRUCTURE OF FIMH IN COMPLEX WITH 3'-CHLORO-4'-(ALPHA-D-MANNOPYRANOSYLOXY)-BIPHENYL-4-CARBONITRILE | | Descriptor: | PROTEIN FIMH, 3'-chloro-4'-(alpha-D-mannopyranosyloxy)biphenyl-4-carbonitrile | | Authors: | Kleeb, S., Pang, L., Mayer, K., Sigl, A., Eris, D., Preston, R.C., Zihlmann, P., Abgottspon, D., Hutter, A., Scharenberg, M., Jian, X., Navarra, G., Rabbani, S., Smiesko, M., Luedin, N., Jakob, R.P., Schwardt, O., Maier, T., Sharpe, T., Ernst, B. | | Deposit date: | 2014-03-10 | | Release date: | 2015-02-25 | | Last modified: | 2019-10-23 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile.
J.Med.Chem., 58, 2015
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4Z42 | | CRYSTAL STRUCTURE OF UREASE FROM YERSINIA ENTEROCOLITICA | | Descriptor: | Urease subunit gamma, Urease subunit beta, Urease subunit alpha, ... | | Authors: | Studer, G., Jakob, R.P., Mahi, M.A., Wiesand, U., Schwede, T., Maier, T. | | Deposit date: | 2015-04-01 | | Release date: | 2016-04-13 | | Last modified: | 2018-11-21 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Crystal structure of urease from Yersinia enterocolitica
To Be Published
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5L4T | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 2-DEOXY-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 2-Deoxy-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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5L4U | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 2-FLUORO-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 2-Fluoro-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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5L4W | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 3-FLUORO-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 3-Fluoro-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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5L4X | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 4-DEOXY-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 4-Deoxy-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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5L4Y | | CRYSTAL STRUCTURE OF FIMH LECTIN DOMAIN IN COMPLEX WITH 4-FLUORO-HEPTYLMANNOSIDE | | Descriptor: | Protein FimH, 4-Fluoro-Heptylmannoside | | Authors: | Jakob, R.P., Zihlmann, P., Rabbani, S., Maier, T., Ernst, B. | | Deposit date: | 2016-05-26 | | Release date: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible
To Be Published
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5MUC | | CRYSTAL STRUCTURE OF THE FIMH LECTIN DOMAIN IN COMPLEX WITH 1,5-ANHYDROMANNITOL | | Descriptor: | Protein FimH, 1,5-Anhydromannitol | | Authors: | Jakob, R.P., Rabbani, S., Ernst, B., Maier, T. | | Deposit date: | 2017-01-13 | | Release date: | 2018-02-14 | | Last modified: | 2018-09-12 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists.
Chemistry, 24, 2018
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6G2R | | CRYSTAL STRUCTURE OF FIMH IN COMPLEX WITH A TETRAFLOURINATED BIPHENYL ALPHA D-MANNOSIDE | | Descriptor: | Type 1 fimbrin D-mannose specific adhesin, 4-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]-2,3,5,6-tetrakis(fluoranyl)benzenecarbonitrile, SULFATE ION, ... | | Authors: | Jakob, R.P., Schoenemann, W., Cramer, J., Muehlethaler, T., Daetwyler, P., Zihlmann, P., Fiege, B., Sager, C.P., Smiesko, M., Rabbani, S., Eris, D., Schwardt, O., Maier, T., Ernst, B. | | Deposit date: | 2018-03-23 | | Release date: | 2019-03-20 | | Last modified: | 2019-04-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Improvement of Aglycone pi-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists.
Chemmedchem, 14, 2019
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6G2S | | CRYSTAL STRUCTURE OF FIMH IN COMPLEX WITH A PENTAFLOURINATED BIPHENYL ALPHA D-MANNOSIDE | | Descriptor: | Type 1 fimbrin D-mannose specific adhesin, (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol, SULFATE ION | | Authors: | Jakob, R.P., Schoenemann, W., Cramer, J., Muehlethaler, T., Daetwyler, P., Zihlmann, P., Fiege, B., Sager, C.P., Smiesko, M., Rabbani, S., Eris, D., Schwardt, O., Maier, T., Ernst, B. | | Deposit date: | 2018-03-23 | | Release date: | 2019-03-20 | | Last modified: | 2019-04-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Improvement of Aglycone pi-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists.
Chemmedchem, 14, 2019
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6GTV | | CRYSTAL STRUCTURE OF A FIMH*DSG COMPLEX FROM E.COLI F18 WITH BOUND TRIMANNOSE | | Descriptor: | FimH protein, FimG protein, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Jakob, R.P., Sauer, M.M., Luber, T., Canonica, F., Navarra, G., Ernst, B., Unverzagt, C., Maier, T., Glockshuber, R. | | Deposit date: | 2018-06-19 | | Release date: | 2019-01-16 | | Last modified: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets.
J.Am.Chem.Soc., 141, 2019
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