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3JSZ
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BU of 3jsz by Molmil
Legionella pneumophila glucosyltransferase Lgt1 N293A with UDP-Glc
Descriptor: MAGNESIUM ION, Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O.
Deposit date:2009-09-11
Release date:2010-02-02
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
3JT1
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BU of 3jt1 by Molmil
Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form
Descriptor: Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE
Authors:Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O.
Deposit date:2009-09-11
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
5UP2
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BU of 5up2 by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GluN2B-specific Fab, ...
Authors:Lu, W, Du, J, Goehring, A, Gouaux, E.
Deposit date:2017-02-01
Release date:2017-03-22
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
5UOW
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BU of 5uow by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a GluN2B-specific Fab, at pH 6.5
Descriptor: (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Lu, W, Du, J, Goehring, A, Gouaux, E.
Deposit date:2017-02-01
Release date:2017-03-22
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
8HZ8
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BU of 8hz8 by Molmil
Structure of PPIA in complex with the peptide of NRF2
Descriptor: NRF2 peptide, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Authors:Wanyan, W, Hui, M, Jin, H, Lu, W.
Deposit date:2023-01-08
Release date:2024-03-13
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:PPIA dictates NRF2 stability to promote lung cancer progression.
Nat Commun, 15, 2024
6UIW
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BU of 6uiw by Molmil
Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state
Descriptor: Calcium homeostasis modulator protein 2, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Lu, W, Du, J, Choi, W.
Deposit date:2019-10-01
Release date:2019-11-27
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6UIV
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BU of 6uiv by Molmil
Cryo-EM structure of human CALHM2 in an active/open state
Descriptor: Calcium homeostasis modulator protein 2
Authors:Lu, W, Du, J, Choi, W.
Deposit date:2019-10-01
Release date:2019-11-27
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6UIX
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BU of 6uix by Molmil
Cryo-EM structure of human CALHM2 gap junction
Descriptor: Calcium homeostasis modulator protein 2
Authors:Lu, W, Du, J, Choi, W.
Deposit date:2019-10-01
Release date:2019-11-27
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
6CUD
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BU of 6cud by Molmil
Structure of the human TRPC3 in a lipid-occupied, closed state
Descriptor: (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lu, W, Du, J, Fan, C, Choi, W.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018
6WBK
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BU of 6wbk by Molmil
Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal tail
Descriptor: Pannexin-1
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.01 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
6WBN
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BU of 6wbn by Molmil
Cryo-EM structure of human Pannexin 1 channel N255A mutant, gap junction
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, DIACYL GLYCEROL, ...
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
6WBM
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BU of 6wbm by Molmil
Cryo-EM structure of human Pannexin 1 channel N255A mutant
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, DIACYL GLYCEROL, ...
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
7JNA
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BU of 7jna by Molmil
Cryo-EM structure of human proton-activated chloride channel PAC at pH 8
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel
Authors:Lu, W, Ruan, R, Du, J.
Deposit date:2020-08-04
Release date:2020-11-11
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures and pH-sensing mechanism of the proton-activated chloride channel.
Nature, 588, 2020
7JNC
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BU of 7jnc by Molmil
cryo-EM structure of human proton-activated chloride channel PAC at pH 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel
Authors:Lu, W, Ruan, R, Du, J.
Deposit date:2020-08-04
Release date:2020-11-11
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Structures and pH-sensing mechanism of the proton-activated chloride channel.
Nature, 588, 2020
6WBL
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BU of 6wbl by Molmil
Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal tail, in complex with CBX
Descriptor: CARBENOXOLONE, Pannexin-1
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.13 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
6WBI
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BU of 6wbi by Molmil
Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in complex with CBX
Descriptor: CARBENOXOLONE, Pannexin-1
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.39 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
6WBF
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BU of 6wbf by Molmil
Cryo-EM structure of wild type human Pannexin 1 channel
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
6WBG
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BU of 6wbg by Molmil
Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Lu, W, Du, J, Ruan, Z.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
2V5Y
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BU of 2v5y by Molmil
Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION
Authors:Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y.
Deposit date:2007-07-11
Release date:2007-09-11
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism.
Science, 317, 2007
3SGQ
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BU of 3sgq by Molmil
GLN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7
Descriptor: Ovomucoid, PHOSPHATE ION, Streptogrisin B
Authors:Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G.
Deposit date:1999-03-25
Release date:2003-08-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's
To be Published
3JAE
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BU of 3jae by Molmil
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1
Authors:Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
Deposit date:2015-06-08
Release date:2015-09-09
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
3JAD
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BU of 3jad by Molmil
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, STRYCHNINE
Authors:Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
Deposit date:2015-06-08
Release date:2015-09-09
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
9B94
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BU of 9b94 by Molmil
Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-22
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B91
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BU of 9b91 by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B90
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BU of 9b90 by Molmil
Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
Authors:Hu, J, Lu, W, Du, J.
Deposit date:2024-04-01
Release date:2024-05-15
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024

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