3JSZ | | LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1 N293A WITH UDP-GLC | | Descriptor: | Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE, MAGNESIUM ION | | Authors: | Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O. | | Deposit date: | 2009-09-11 | | Release date: | 2010-02-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
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3JT1 | | LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE LGT1, UDP-BOUND FORM | | Descriptor: | Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE | | Authors: | Lu, W., Du, J., Belyi, Y., Stahl, M., Zivilikidis, T., Gerhardt, S., Aktories, K., Einsle, O. | | Deposit date: | 2009-09-11 | | Release date: | 2010-02-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
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5UOW | | TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5 | | Descriptor: | N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ... | | Authors: | Lu, W., Du, J., Goehring, A., Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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5UP2 | | TRIHETEROMERIC NMDA RECEPTOR GLUN1/GLUN2A/GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, RO 25-6981, MK-801 AND A GLUN2B-SPECIFIC FAB, AT PH 6.5 | | Descriptor: | N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ... | | Authors: | Lu, W., Du, J., Goehring, A., Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2017-11-08 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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6CUD | | STRUCTURE OF THE HUMAN TRPC3 IN A LIPID-OCCUPIED, CLOSED STATE | | Descriptor: | Short transient receptor potential channel 3, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (2R)-3-hydroxypropane-1,2-diyl dihexanoate, ... | | Authors: | Lu, W., Du, J., Fan, C., Choi, W. | | Deposit date: | 2018-03-25 | | Release date: | 2018-05-16 | | Last modified: | 2018-05-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018
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2FDP | | CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO-ETHYLENE INHIBITOR | | Descriptor: | Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE | | Authors: | Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D. | | Deposit date: | 2005-12-14 | | Release date: | 2006-01-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
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2ZJK | |
2ZJL | | CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-BROMO-2,3-DIMETHOXY-BENZYL)-PIPERIDIN-4-YL]-4-MERCAPTO-BUTYRAMIDE | | Descriptor: | Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | | Authors: | Randal, M., Lam, M.B., Lu, W., Romanowski, M.J. | | Deposit date: | 2008-03-07 | | Release date: | 2009-01-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
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3H6C | |
3HJ2 | |
3HJD | |
3IWY | |
3LNZ | |
3LO1 | |
3LO2 | | CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y21A MUTANT) | | Descriptor: | Neutrophil defensin 1, (4S)-2-METHYL-2,4-PENTANEDIOL, trifluoroacetic acid, ... | | Authors: | Pazgier, M., Lu, W. | | Deposit date: | 2010-02-03 | | Release date: | 2010-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
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3LO4 | |
3LO6 | |
3LO9 | |
3LOE | |
3LVX | |
1NR2 | | HIGH RESOLUTION CRYSTAL STRUCTURES OF THYMUS AND ACTIVATION-REGULATED CHEMOKINE | | Descriptor: | Thymus and activation-regulated chemokine | | Authors: | Asojo, O.A., Boulegue, C., Hoover, D.M., Lu, W., Lubkowski, J. | | Deposit date: | 2003-01-23 | | Release date: | 2003-08-05 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structures of thymus and activation-regulated chemokine (TARC).
Acta Crystallogr.,Sect.D, 59, 2003
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1NR4 | | HIGH RESOLUTION CRYSTAL STRUCTURES OF THYMUS AND ACTIVATION-REGULATED CHEMOKINE | | Descriptor: | Thymus and activation-regulated chemokine, SULFATE ION | | Authors: | Asojo, O.A., Boulegue, C., Hoover, D.M., Lu, W., Lubkowski, J. | | Deposit date: | 2003-01-23 | | Release date: | 2003-08-05 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Structures of thymus and activation-regulated chemokine (TARC).
Acta Crystallogr.,Sect.D, 59, 2003
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1SGD | | ASP 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 | | Descriptor: | Streptogrisin B, Ovomucoid, PHOSPHATE ION | | Authors: | Huang, K., Lu, W., Anderson, S., Laskowski Jr., M., James, M.N.G. | | Deposit date: | 1999-03-25 | | Release date: | 2003-08-26 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's
To be Published
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1SGE | | GLU 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 | | Descriptor: | Streptogrisin B, Ovomucoid, PHOSPHATE ION | | Authors: | Huang, K., Lu, W., Anderson, S., Laskowski Jr., M., James, M.N.G. | | Deposit date: | 1999-03-25 | | Release date: | 2003-08-26 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pHs
To be Published
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1SGN | | ASN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B | | Descriptor: | Streptogrisin B, Ovomucoid, PHOSPHATE ION | | Authors: | Huang, K., Lu, W., Anderson, S., Laskowski Jr., M., James, M.N.G. | | Deposit date: | 1999-03-25 | | Release date: | 2003-08-26 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with
Streptomyces griseus Protease B at Various pHs
To be Published
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