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4F4P
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BU of 4f4p by Molmil
SYK in COMPLEX WITH LIGAND LASW836
Descriptor: N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, Tyrosine-protein kinase SYK
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-05-11
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Highly potent aminopyridines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4DFN
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BU of 4dfn by Molmil
Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor
Descriptor: 3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide, Tyrosine-protein kinase SYK
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-01-24
Release date:2012-04-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Pyrazine-based Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4DFL
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BU of 4dfl by Molmil
Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide, SULFATE ION, ...
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-01-24
Release date:2012-04-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Pyrazine-based Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
9EY8
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BU of 9ey8 by Molmil
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (s)-amino-L-tyrosine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ng, Y.M, Soler-Lopez, M.
Deposit date:2024-04-09
Release date:2024-05-01
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Chembiochem, 25, 2024
9EY5
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BU of 9ey5 by Molmil
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (S)-2,4-dihydroxyphenylalanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-hydroxy-L-tyrosine, ...
Authors:Ng, Y.M, Soler-Lopez, M.
Deposit date:2024-04-09
Release date:2024-05-22
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Chembiochem, 25, 2024
9EY6
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BU of 9ey6 by Molmil
Crystal structure of human tyrosinase-related protein 1 (TYRP1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5,6-dihydroxyindole-2-carboxylic acid oxidase, ...
Authors:Ng, Y.M, Soler-Lopez, M.
Deposit date:2024-04-09
Release date:2024-05-22
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.228 Å)
Cite:Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Chembiochem, 25, 2024
9EY7
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BU of 9ey7 by Molmil
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (R)-2,4-dihydroxyphenylalanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-hydroxy-L-tyrosine, ...
Authors:Ng, Y.M, Soler-Lopez, M.
Deposit date:2024-04-09
Release date:2024-05-22
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Chembiochem, 25, 2024
5M8N
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BU of 5m8n by Molmil
Crystal structure of human tyrosinase related protein 1 in complex with mimosine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M8M
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BU of 5m8m by Molmil
Crystal structure of human tyrosinase related protein 1 in complex with kojic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M8Q
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BU of 5m8q by Molmil
Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with kojic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M8P
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BU of 5m8p by Molmil
Crystal structure of human tyrosinase related protein 1 in complex with tyrosine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M8T
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BU of 5m8t by Molmil
Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone
Descriptor: 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
5M8O
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BU of 5m8o by Molmil
Crystal structure of human tyrosinase related protein 1 in complex with tropolone
Descriptor: 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2016-10-29
Release date:2017-07-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
1UUS
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BU of 1uus by Molmil
Structure of an activated Dictyostelium STAT in its DNA-unbound form
Descriptor: STAT PROTEIN
Authors:Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W.
Deposit date:2004-01-09
Release date:2004-03-26
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form
Mol.Cell, 13, 2004
1UUR
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BU of 1uur by Molmil
Structure of an activated Dictyostelium STAT in its DNA-unbound form
Descriptor: STATA PROTEIN
Authors:Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W.
Deposit date:2004-01-09
Release date:2004-03-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form
Mol.Cell, 13, 2004
8VKT
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BU of 8vkt by Molmil
Crystallographic structure of dimetalated DapE from Enterococcus faecium
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Probable succinyl-diaminopimelate desuccinylase, ...
Authors:Gonzalez-Segura, L, Diaz-Vilchis, A, Terrazas-Lopez, M, Diaz-Sanchez, A.G.
Deposit date:2024-01-09
Release date:2024-05-29
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity.
Int.J.Biol.Macromol., 270, 2024
1K1B
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BU of 1k1b by Molmil
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family
Descriptor: B-cell lymphoma 3-encoded protein
Authors:Michel, F, Soler-Lopez, M, Petosa, C, Cramer, P, Siebenlist, U, Mueller, C.W.
Deposit date:2001-09-24
Release date:2001-11-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
EMBO J., 20, 2001
1W9C
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BU of 1w9c by Molmil
Proteolytic fragment of CRM1 spanning six C-terminal HEAT repeats
Descriptor: CRM1 PROTEIN
Authors:Petosa, C, Schoehn, G, Askjaer, P, Bauer, U, Moulin, M, Steuerwald, U, Soler-Lopez, M, Baudin, F, Mattaj, I.W, Muller, C.W.
Deposit date:2004-10-08
Release date:2004-12-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architecture of Crm1-Exportin 1 Suggests How Cooperativity is Achieved During Formation of a Nuclear Export Complex
Mol.Cell, 16, 2004
1K1A
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BU of 1k1a by Molmil
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family
Descriptor: B-cell lymphoma 3-encoded protein
Authors:Michel, F, Soler-Lopez, M, Petosa, C, Cramer, P, Siebenlist, U, Mueller, C.W.
Deposit date:2001-09-24
Release date:2001-11-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
EMBO J., 20, 2001
2WP2
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BU of 2wp2 by Molmil
Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.
Descriptor: BROMODOMAIN TESTIS-SPECIFIC PROTEIN, HISTONE H4
Authors:Moriniere, J, Rousseaux, S, Steuerwald, U, Soler-Lopez, M, Curtet, S, Vitte, A.-L, Govin, J, Gaucher, J, Sadoul, K, Hart, D.J, Krijgsveld, J, Khochbin, S, Mueller, C.W, Petosa, C.
Deposit date:2009-08-02
Release date:2009-09-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Cooperative Binding of Two Acetylation Marks on a Histone Tail by a Single Bromodomain.
Nature, 461, 2009
2WP1
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BU of 2wp1 by Molmil
Structure of Brdt bromodomain 2 bound to an acetylated histone H3 peptide
Descriptor: BROMODOMAIN TESTIS-SPECIFIC PROTEIN, HISTONE H3
Authors:Moriniere, J, Rousseaux, S, Steuerwald, U, Soler-Lopez, M, Curtet, S, Vitte, A.-L, Govin, J, Gaucher, J, Sadoul, K, Hart, D.J, Krijgsveld, J, Khochbin, S, Mueller, C.W, Petosa, C.
Deposit date:2009-08-02
Release date:2009-09-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cooperative Binding of Two Acetylation Marks on a Histone Tail by a Single Bromodomain.
Nature, 461, 2009
8PHE
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BU of 8phe by Molmil
ACAD9-WT in complex with ECSIT-CTER
Descriptor: Complex I assembly factor ACAD9, mitochondrial, Evolutionarily conserved signaling intermediate in Toll pathway
Authors:McGregor, L, Acajjaoui, S, Desfosses, A, Saidi, M, Bacia-Verloop, M, Schwarz, J.J, Juyoux, P, Von Velsen, J, Bowler, M.W, McCarthy, A, Kandiah, E, Gutsche, I, Soler-Lopez, M.
Deposit date:2023-06-19
Release date:2024-01-24
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.
Nat Commun, 14, 2023
8PHF
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BU of 8phf by Molmil
Cryo-EM structure of human ACAD9-S191A
Descriptor: Complex I assembly factor ACAD9, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE
Authors:McGregor, L, Acajjaoui, S, Desfosses, A, Saidi, M, Bacia-Verloop, M, Schwarz, J.J, Juyoux, P, Von Velsen, J, Bowler, M.W, McCarthy, A, Kandiah, E, Gutsche, I, Soler-Lopez, M.
Deposit date:2023-06-19
Release date:2024-01-24
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.
Nat Commun, 14, 2023
5EHA
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BU of 5eha by Molmil
Crystal structure of recombinant MtaL at 1.35 Angstrom resolution
Descriptor: Lectin-like fold protein
Authors:Lai, X.-L, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W.
Deposit date:2015-10-28
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
7UOI
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BU of 7uoi by Molmil
Crystallographic structure of DapE from Enterococcus faecium
Descriptor: GLYCEROL, ZINC ION, succinyl-diaminopimelate desuccinylase
Authors:Gonzalez-Segura, L, Diaz-Vilchis, A, Terrazas-Lopez, M, Diaz-Sanchez, A.G.
Deposit date:2022-04-12
Release date:2023-04-12
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity.
Int.J.Biol.Macromol., 270, 2024

 

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