4DFN

Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor

Summary for 4DFN

Entry DOI	10.2210/pdb4dfn/pdb
Related	4DFL
Descriptor	Tyrosine-protein kinase SYK, 3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide (3 entities in total)
Functional Keywords	protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	32243.20
Authors	Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (deposition date: 2012-01-24, release date: 2012-04-25, Last modification date: 2024-02-28)
Primary citation	Forns, P.,Esteve, C.,Taboada, L.,Alonso, J.A.,Orellana, A.,Maldonado, M.,Carreno, C.,Ramis, I.,Lopez, M.,Miralpeix, M.,Vidal, B. Pyrazine-based Syk kinase inhibitors. Bioorg.Med.Chem.Lett., 22:2784-2788, 2012 Cited by PubMed: 22425453 DOI: 10.1016/j.bmcl.2012.02.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation