4DFN
Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 274 | 31798.7 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase |
| 2 | B (A) | 3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide | non-polymer | 444.5 | 1 | Chemie (0K1) | |||
| 3 | C (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 363 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Glu 636 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31798.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 444.5 | |
| All* | Total formula weight | 32243.2 |
