4DFL

Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor

Summary for 4DFL

• Entry DOI: 10.2210/pdb4dfl/pdb
• Related: 4DFN
• Descriptor: Tyrosine-protein kinase SYK, 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: syk, transferase, kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 32361.29

Authors

Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (deposition date: 2012-01-24, release date: 2012-04-25, Last modification date: 2024-02-28)

Primary citation

Forns, P.,Esteve, C.,Taboada, L.,Alonso, J.A.,Orellana, A.,Maldonado, M.,Carreno, C.,Ramis, I.,Lopez, M.,Miralpeix, M.,Vidal, B.
Pyrazine-based Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22:2784-2788, 2012

PubMed Abstract: A series of aminopyrazines as inhibitors of Syk kinase activity and showing inhibition of LAD2 cells degranulation is described. Optimization of the carboxamide motif with aminomethylpiperidines provided high potency inhibiting Syk but low cellular activity. Amides of cis and trans adamantanol showed good inhibitory activity against Syk as well as remarkable activity in LAD2 cells degranulation assay.

PubMed: 22425453
DOI: 10.1016/j.bmcl.2012.02.087

Experimental method

X-RAY DIFFRACTION (1.98 Å)