4DFL
Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 274 | 31798.7 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (human) | Spleen tyrosine kinase |
| 2 | A | 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide | non-polymer | 404.5 | 1 | Chemie (0K0) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 114 | Chemie (HOH) |
Sequence modifications
A: 363 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Glu 636 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31798.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 562.6 | |
| All* | Total formula weight | 32361.3 |
