9EY5

Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (S)-2,4-dihydroxyphenylalanine

Summary for 9EY5

• Entry DOI: 10.2210/pdb9ey5/pdb
• Descriptor: 5,6-dihydroxyindole-2-carboxylic acid oxidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: melanogenesis, human tyrosinase, tyrosinase inhibitor, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 54225.07

Authors

Ng, Y.M.,Soler-Lopez, M. (deposition date: 2024-04-09, release date: 2024-05-22, Last modification date: 2024-07-03)

• Primary citation: Faure, C.,Min Ng, Y.,Belle, C.,Soler-Lopez, M.,Khettabi, L.,Saidi, M.,Berthet, N.,Maresca, M.,Philouze, C.,Rachidi, W.,Reglier, M.,du Moulinet d'Hardemare, A.,Jamet, H.; Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.; Chembiochem, 25:e202400235-e202400235, 2024; PubMed: 38642076; DOI: 10.1002/cbic.202400235

Experimental method

X-RAY DIFFRACTION (2.61 Å)