9EY8

Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (s)-amino-L-tyrosine

This is a non-PDB format compatible entry.

Summary for 9EY8

• Entry DOI: 10.2210/pdb9ey8/pdb
• Descriptor: 5,6-dihydroxyindole-2-carboxylic acid oxidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• Functional Keywords: melanogenesis, human tyrosinase, tyrosinase inhibitor, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 223727.82

Authors

Ng, Y.M.,Soler-Lopez, M. (deposition date: 2024-04-09, release date: 2024-05-01)

• Primary citation: Faure, C.,Ng, Y.M.,Belle, C.,Soler-Lopez, M.,Khettabi, L.,Saidi, M.,Berthet, N.,Maresca, M.,Philouze, C.,Rachidi, W.,Reglier, M.,du Moullinet d'Hardemare, A.,Jamet, H.; Interactions of phenylalanine derivatives with human tyrosinase: lessons from experimental and theoretical studies.; Chembiochem, :e202400235-e202400235, 2024; PubMed: 38642076; DOI: 10.1002/cbic.202400235

Experimental method

X-RAY DIFFRACTION (2.2 Å)