Author results

19GS
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GLUTATHIONE S-TRANSFERASE P1-1
Descriptor:GLUTATHIONE S-TRANSFERASE, 3,3'-(4,5,6,7-TETRABROMO-3-OXO-1(3H)-ISOBENZOFURANYLIDENE)BIS [6-HYDROXYBENZENESULFONIC ACID]ANION, GLUTATHIONE, ...
Authors:Oakley, A.J., Lo Bello, M., Parker, M.W.
Deposit date:1997-12-14
Release date:1998-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
20GS
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GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH CIBACRON BLUE
Descriptor:GLUTATHIONE S-TRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CIBACRON BLUE
Authors:Oakley, A.J., Lo Bello, M., Nuccetelli, M., Mazzetti, A.P., Parker, M.W.
Deposit date:1997-12-16
Release date:1998-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
12GS
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GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-NONYL-GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-nonyl-L-cysteinylglycine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Parker, M.W.
Deposit date:1997-11-19
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site).
J.Mol.Biol., 291, 1999
13GS
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GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE, 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, ...
Authors:Oakley, A.J., Lo Bello, M., Parker, M.W.
Deposit date:1997-11-20
Release date:1999-01-13
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site).
J.Mol.Biol., 291, 1999
18GS
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GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE S-(2,4 DINITROBENZENE), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-12-07
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
1LBK
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CRYSTAL STRUCTURE OF A RECOMBINANT GLUTATHIONE TRANSFERASE, CREATED BY REPLACING THE LAST SEVEN RESIDUES OF EACH SUBUNIT OF THE HUMAN CLASS PI ISOENZYME WITH THE ADDITIONAL C-TERMINAL HELIX OF HUMAN CLASS ALPHA ISOENZYME
Descriptor:Glutathione S-transferase class pi chimaera (CODA), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ...
Authors:Kong, G.K.W., Micaloni, C., Mazzetti, A.P., Nuccetelli, M., Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn, J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M.
Deposit date:2002-04-04
Release date:2002-04-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.
J.Mol.Biol., 325, 2003
11GS
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GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE, ETHACRYNIC ACID, ...
Authors:Oakley, A.J., Lo Bello, M., Mazzetti, A.P., Federici, G., Parker, M.W.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS Lett., 419, 1997
14GS
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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1
Descriptor:GLUTATHIONE S-TRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-11-29
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
16GS
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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3
Descriptor:GLUTATHIONE S-TRANSFERASE, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., Parker, M.W.
Deposit date:1997-11-30
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
17GS
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GLUTATHIONE S-TRANSFERASE P1-1
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J., Lo Bello, M., Parker, M.W.
Deposit date:1997-12-07
Release date:1998-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Glutathione S-transferase P1-1
To be published
4GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y108F MUTANT
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A., Rossjohn, J., Parker, M.
Deposit date:1997-01-20
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.
Biochemistry, 36, 1997
22GS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y49F MUTANT
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Oakley, A.J.
Deposit date:1998-03-10
Release date:1999-03-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione.
J.Biol.Chem., 278, 2003
2GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, ETHACRYNIC ACID, ...
Authors:Oakley, A.J., Rossjohn, J., Parker, M.W.
Deposit date:1996-10-29
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
3GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE
Descriptor:GLUTATHIONE S-TRANSFERASE P1-1, SULFATE ION, GLUTATHIONE, ...
Authors:Oakley, A.J., Rossjohn, J., Parker, M.W.
Deposit date:1996-10-29
Release date:1997-11-12
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
1GSS
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THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
Descriptor:GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-hexyl-L-cysteinylglycine
Authors:Reinemer, P., Dirr, H.W., Ladenstein, R., Lobello, M., Federici, G., Huber, R., Parker, M.W.
Deposit date:1992-05-28
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
J.Mol.Biol., 227, 1992
2A2R
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE PI IN COMPLEX WITH S-NITROSOGLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2A2S
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE IN COMPLEX WITH S-NITROSOGLUTATHIONE IN THE ABSENCE OF REDUCING AGENT
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
3KM6
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CRYSTAL STRUCTURE OF THE HUMAN GST PI C47S/Y108V DOUBLE MUTANT IN COMPLEX WITH THE ETHACRYNIC ACID-GLUTATHIONE CONJUGATE
Descriptor:Glutathione S-transferase P, ETHACRYNIC ACID, GLUTATHIONE, ...
Authors:Parker, L.J.
Deposit date:2009-11-10
Release date:2010-03-23
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.
J.Mol.Recognit., 24
3DD3
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CRYSTAL STRUCTURE OF THE GLUTATHIONE TRANSFERASE PI ENZYME IN COMPLEX WITH THE BIFUNCTIONAL INHIBITOR, ETHARAPTA
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (eta6-benzene)ruthenium, ...
Authors:Parker, L.J.
Deposit date:2008-06-05
Release date:2009-04-21
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Rational design of an organometallic glutathione transferase inhibitor
Angew.Chem.Int.Ed.Engl., 48, 2009
3DGQ
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CRYSTAL STRUCTURE OF THE GLUTATHIONE TRANSFERASE PI ENZYME IN COMPLEX WITH THE BIFUNCTIONAL INHIBITOR, ETHARAPTA
Descriptor:Glutathione S-transferase P, CHLORIDE ION, ETHACRYNIC ACID, ...
Authors:Parker, L.J.
Deposit date:2008-06-15
Release date:2009-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Rational design of an organometallic glutathione transferase inhibitor
Angew.Chem.Int.Ed.Engl., 48, 2009
3HJM
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI Y108V MUTANT
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Parker, L.J.
Deposit date:2009-05-22
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3HJO
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE PI Y108V MUTANT IN COMPLEX WITH THE GLUTATHIONE CONJUGATE OF ETHACRYNIC ACID
Descriptor:Glutathione S-transferase P, GLUTATHIONE, ETHACRYNIC ACID, ...
Authors:Parker, L.J.
Deposit date:2009-05-22
Release date:2009-09-22
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3HKR
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE PI Y108V MUTANT
Descriptor:Glutathione S-transferase P, CALCIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Parker, L.J.
Deposit date:2009-05-25
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3KMN
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CRYSTAL STRUCTURE OF THE HUMAN APO GST PI C47S/Y108V DOUBLE MUTANT
Descriptor:Glutathione S-transferase P, CALCIUM ION, CARBONATE ION, ...
Authors:Parker, L.J.
Deposit date:2009-11-11
Release date:2010-03-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V
to be published
3KMO
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CRYSTAL STRUCTURE OF THE HUMAN GST PI C47S/Y108V DOUBLE MUTANT IN COMPLEX WITH THE ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (GROWN IN THE ABSENCE OF THE REDUCING AGENT DTT)
Descriptor:Glutathione S-transferase P, GLUTATHIONE, CALCIUM ION, ...
Authors:Parker, L.J.
Deposit date:2009-11-11
Release date:2010-03-23
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V
To be Published
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