1SI5
| Protease-like domain from 2-chain hepatocyte growth factor | Descriptor: | hepatocyte growth factor | Authors: | Kirchhofer, D, Yao, X, Peek, M, Eigenbrot, C, Lipari, M.T, Billeci, K.L, Maun, H.R, Moran, P, Santell, L, Lazarus, R.A. | Deposit date: | 2004-02-27 | Release date: | 2004-12-28 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling J.Biol.Chem., 279, 2004
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1PG7
| Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab | Descriptor: | humanized antibody D3H44, murine antibody 6A6 Fab fragment | Authors: | Eigenbrot, C, Meng, Y.G, Krishnamurthy, R, Lipari, M.T, Presta, L, Devaux, B, Wong, T, Moran, P, Bullens, S, Kirchhofer, D. | Deposit date: | 2003-05-27 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. J.Mol.Biol., 331, 2003
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6VVU
| Anti-Tryptase fab E104.v1 bound to tryptase | Descriptor: | CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... | Authors: | Ultsch, M, Koerber, J.T. | Deposit date: | 2020-02-18 | Release date: | 2020-12-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge. Nat Commun, 11, 2020
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6MV5
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6O1F
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3K2U
| Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Fab fragment, ... | Authors: | Ganesan, R, Eigenbrot, C, Shia, S. | Deposit date: | 2009-09-30 | Release date: | 2009-12-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 17, 2009
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6E4Y
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6E4Z
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2R0K
| Protease domain of HGFA with inhibitor Fab58 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain of Fab58, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2WUB
| Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp | Descriptor: | FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, FAB FRAGMENT FAB40.DELTATRP LIGHT CHAIN, HEPATOCYTE GROWTH FACTOR ACTIVATOR LONG CHAIN, ... | Authors: | Ganesan, R, Eigenbrot, C, Shia, S. | Deposit date: | 2009-10-01 | Release date: | 2009-12-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
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2R0L
| Short Form HGFA with Inhibitory Fab75 | Descriptor: | Hepatocyte growth factor activator, antibody heavy chain, Fab portion only, ... | Authors: | Eigenbrot, C, Shia, S. | Deposit date: | 2007-08-20 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2WUC
| Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp and Ac-KQLR-chloromethylketone | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-KQLR-CHLOROMETHYLKETONE INHIBITOR, FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, ... | Authors: | Ganesan, R, Eigenbrot, C, Shia, S. | Deposit date: | 2009-10-01 | Release date: | 2009-12-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17, 2009
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3TJO
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3TJN
| HtrA1 catalytic domain, apo form | Descriptor: | Serine protease HTRA1 | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2011-08-24 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
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3TJQ
| N-domain of HtrA1 | Descriptor: | CHLORIDE ION, GLYCEROL, PLATINUM (II) ION, ... | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2011-08-24 | Release date: | 2012-05-16 | Last modified: | 2012-06-27 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
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1SHY
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