6E4Y
Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9, unmodified
Summary for 6E4Y
Entry DOI | 10.2210/pdb6e4y/pdb |
Descriptor | 6E2 heavy chain, 6E2 light chain, Proprotein convertase subtilisin/kexin type 9, ... (6 entities in total) |
Functional Keywords | antibody, hydrolase, pcsk9, fab complex, immune system |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 51061.70 |
Authors | Ultsch, M.H.,Kirchhofer, D.K. (deposition date: 2018-07-18, release date: 2019-04-10, Last modification date: 2023-10-11) |
Primary citation | Ultsch, M.,Li, W.,Eigenbrot, C.,Di Lello, P.,Lipari, M.T.,Gerhardy, S.,AhYoung, A.P.,Quinn, J.,Franke, Y.,Chen, Y.,Kong Beltran, M.,Peterson, A.,Kirchhofer, D. Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain. J. Mol. Biol., 431:885-903, 2019 Cited by PubMed: 30653992DOI: 10.1016/j.jmb.2018.11.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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