6E4Y
Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9, unmodified
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 301 |
| Chain | Residue |
| H | ASP53 |
| L | ASP60 |
| L | HOH447 |
| P | GLU48 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CL H 302 |
| Chain | Residue |
| P | TYR38 |
| H | GLY94 |
| H | ILE96 |
| H | PHE97 |
| H | VAL98 |
| H | ASN99 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue ZN L 301 |
| Chain | Residue |
| H | HIS164 |
| L | ASN137 |
| L | ASN138 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN L 302 |
| Chain | Residue |
| L | ARG61 |
| L | GLU79 |
| L | GLU81 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue ZN P 101 |
| Chain | Residue |
| P | ASP37 |
| P | GLU40 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR194-HIS200 | |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"16912035","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"18498363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
