6E4Y

Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9, unmodified

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN H 301

Chain	Residue
H	ASP53
L	ASP60
L	HOH447
P	GLU48

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site_id	AC2
Number of Residues	6
Details	binding site for residue CL H 302

Chain	Residue
P	TYR38
H	GLY94
H	ILE96
H	PHE97
H	VAL98
H	ASN99

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site_id	AC3
Number of Residues	3
Details	binding site for residue ZN L 301

Chain	Residue
H	HIS164
L	ASN137
L	ASN138

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site_id	AC4
Number of Residues	3
Details	binding site for residue ZN L 302

Chain	Residue
L	ARG61
L	GLU79
L	GLU81

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site_id	AC5
Number of Residues	2
Details	binding site for residue ZN P 101

Chain	Residue
P	ASP37
P	GLU40

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035

Chain	Residue	Details
P	TYR38

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039

Chain	Residue	Details
P	SER47

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