Author results

5CHL
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STRUCTURAL BASIS OF H2A.Z RECOGNITION BY YL1 HISTONE CHAPERONE COMPONENT OF SRCAP/SWR1 CHROMATIN REMODELING COMPLEX
Descriptor:Vacuolar protein sorting-associated protein 72 homolog, Histone H2A.Z
Authors:Shan, S., Liang, X., Pan, L., Wu, C., Zhou, Z.
Deposit date:2015-07-10
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1
Nat.Struct.Mol.Biol., 23, 2016
1HV4
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CRYSTAL STRUCTURE ANALYSIS OF BAR-HEAD GOOSE HEMOGLOBIN (DEOXY FORM)
Descriptor:HEMOGLOBIN ALPHA-A CHAIN, HEMOGLOBIN BETA CHAIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Liang, Y., Hua, Z., Liang, X., Xu, Q., Lu, G.
Deposit date:2001-01-07
Release date:2001-01-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of bar-headed goose hemoglobin in deoxy form: the allosteric mechanism of a hemoglobin species with high oxygen affinity.
J.Mol.Biol., 313, 2001
4N9B
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhai, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (2.859 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9C
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 5-nitro-1H-benzimidazole, PHOSPHATE ION
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9D
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, PHOSPHATE ION, ...
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9E
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FRAGMENT-BASED DESIGN OF 3-AMINOPYRIDINE-DERIVED AMIDES AS POTENT INHIBITORS OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
Descriptor:Nicotinamide phosphoribosyltransferase, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, PHOSPHATE ION, ...
Authors:Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
Deposit date:2013-10-20
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
1GWZ
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Descriptor:SHP-1
Authors:Yang, J., Liang, X., Niu, T., Meng, W., Zhao, Z., Zhou, G.W.
Deposit date:1998-08-22
Release date:1999-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 273, 1998
2B3O
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE SHP-1
Descriptor:Tyrosine-protein phosphatase, non-receptor type 6
Authors:Yang, J., Liu, L., He, D., Song, X., Liang, X., Zhao, Z.J., Zhou, G.W.
Deposit date:2005-09-20
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 278, 2003
4NFT
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CRYSTAL STRUCTURE OF HUMAN LNKH2B-H2A.Z-ANP32E
Descriptor:Histone H2B type 2-E, Histone H2A.Z, Acidic leucine-rich nuclear phosphoprotein 32 family member E
Authors:Shan, S., Pan, L., Mao, Z., Wang, W., Sun, J., Dong, Q., Liang, X., Ding, X., Chen, S., Dai, L., Zhang, Z., Zhu, B., Zhou, Z.
Deposit date:2013-11-01
Release date:2014-04-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z
Cell Res., 24, 2014
6AKO
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CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA
Descriptor:DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ...
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 2019
6AKP
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CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
Descriptor:DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 2019
1PS9
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THE CRYSTAL STRUCTURE AND REACTION MECHANISM OF E. COLI 2,4-DIENOYL COA REDUCTASE
Descriptor:2,4-dienoyl-CoA reductase, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
Authors:Hubbard, P.A., Liang, X., Schulz, H., Kim, J.J.
Deposit date:2003-06-20
Release date:2003-09-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure and reaction mechanism of Escherichia coli 2,4-dienoyl-CoA reductase
J.Biol.Chem., 278, 2003
1YIK
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STRUCTURE OF HEN EGG WHITE LYSOZYME SOAKED WITH CU-CYCLAM
Descriptor:Lysozyme C, CHLORIDE ION, SODIUM ION, ...
Authors:Hunter, T.M., McNae, I.W., Liang, X., Bella, J., Parsons, S., Walkinshaw, M.D., Sadler, P.J.
Deposit date:2005-01-12
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme
Proc.Natl.Acad.Sci.Usa, 102, 2005
1YIL
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STRUCTURE OF HEN EGG WHITE LYSOZYME SOAKED WITH CU2-XYLYLBICYCLAM
Descriptor:Lysozyme C, CHLORIDE ION, SODIUM ION, ...
Authors:Hunter, T.M., McNae, I.W., Liang, X., Bella, J., Parsons, S., Walkinshaw, M.D., Sadler, P.J.
Deposit date:2005-01-12
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme
Proc.Natl.Acad.Sci.Usa, 102, 2005
1YP1
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CRYSTAL STRUCTURE OF A NON-HEMORRHAGIC FIBRIN(OGEN)OLYTIC METALLOPROTEINASE FROM VENOM OF AGKISTRODON ACUTUS
Descriptor:FII, KNL, ZINC ION
Authors:Lou, Z., Hou, J., Chen, J., Liang, X., Qiu, P., Liu, Y., Li, M., Rao, Z.
Deposit date:2005-01-28
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus
J.Struct.Biol., 152, 2005
3QKW
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STRUCTURE OF STREPTOCOCCUS PARASANGUNINI GTF3 GLYCOSYLTRANSFERASE
Descriptor:Nucleotide sugar synthetase-like protein, URIDINE-5'-DIPHOSPHATE
Authors:Zhu, F., Erlandsen, H., Huang, Y., Ding, L., Zhou, M., Liang, X., Ma, J.-B., Wu, H.
Deposit date:2011-02-01
Release date:2011-06-08
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.287 Å)
Cite:Structural and Functional Analysis of a New Subfamily of Glycosyltransferases Required for Glycosylation of Serine-rich Streptococcal Adhesins.
J.Biol.Chem., 286, 2011
4YR6
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FAB FRAGMENT OF 5G6 IN COMPLEX WITH EPITOPE PEPTIDE
Descriptor:heavy chain of 5G6, light chain of 5G6, ACE-LYS-LEU-ARG-GLY-VAL-LEU-GLN-GLY-HIS-LEU, ...
Authors:Tao, Y., Mo, X., Li, R.
Deposit date:2015-03-14
Release date:2016-03-09
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Specific inhibition of GPIBA shedding improves post-transfusion recovery and preserves adhesive function during prolonged storage of human apheresis platelets
To Be Published
3PS1
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI LPXC/LPC-011 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.
Bioorg.Med.Chem., 19, 2011
3PS2
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI LPXC/LPC-012 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(3-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-nitroso-1-oxobutan-2-yl]benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.
Bioorg.Med.Chem., 19, 2011
3PS3
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI LPXC/LPC-053 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-3-hydroxy-1-nitroso-1-oxobutan-2-yl]benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.
Bioorg.Med.Chem., 19, 2011
2ND4
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A DISTINCT SORTASE SRTB ANCHORS AND PROCESSES A STREPTOCOCCAL ADHESIN ABPA WITH A NOVEL STRUCTURAL PROPERTY
Descriptor:Amylase-binding protein AbpA
Authors:Liu, B., Zhu, F., Wu, H., Matthews, S.
Deposit date:2016-05-05
Release date:2016-09-07
Method:SOLUTION NMR
Cite:A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.
Sci Rep, 6, 2016
4LCF
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CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LPXC/LPC-014 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-histidinamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2013-06-21
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
J.Med.Chem., 56, 2013
4LCG
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CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LPXC/LPC-050 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-L-tyrosinamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2013-06-21
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.568 Å)
Cite:Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
J.Med.Chem., 56, 2013
4LCH
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CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LPXC/LPC-051 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-beta-methyl-L-tyrosinamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2013-06-21
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.596 Å)
Cite:Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
J.Med.Chem., 56, 2013
5CP3
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CRYSTAL STRUCTURE OF AN ANTIGEN-BINDING FRAGMENT OF MONOCLONAL ANTIBODY AGAINST SULFONAMIDES IN COMPLEX WITH SULFATHIAZOLE
Descriptor:Light Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7, Heavy Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7, 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, ...
Authors:Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X.
Deposit date:2015-07-21
Release date:2015-08-05
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity.
Anal. Chem., 91, 2019
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