Author results

6JYX
  • Download 6jyx
  • View 6jyx
Molmil generated image of 6jyx
STRUCTURE OF CBPJ FROM STREPTOCOCCUS PNEUMONIAE TIGR4
分子名称:Choline binding protein J, CHOLINE ION, DI(HYDROXYETHYL)ETHER
著者Xu, Q., Zhang, J.W., Li, Q., Jiang, Y.L.
登録日2019-04-29
公開日2019-06-05
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the choline-binding protein CbpJ from Streptococcus pneumoniae.
Biochem.Biophys.Res.Commun., 514, 2019
6JY5
  • Download 6jy5
  • View 6jy5
Molmil generated image of 6jy5
STRUCTURE OF CSOS4B FROM HALOTHIOBACILLUS NEAPOLITANUS
分子名称:Unidentified carboxysome polypeptide
著者Zhao, Y.Y., Jiang, Y.L., Chen, Y., Zhou, C.Z., Li, Q.
登録日2019-04-26
公開日2019-06-26
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus alpha-carboxysome.
Biochem.Biophys.Res.Commun., 515, 2019
6J1L
  • Download 6j1l
  • View 6j1l
Molmil generated image of 6j1l
CRYTAL STRUCTURE ANALYSIS OF THE ROR GAMMA(C455E)
分子名称:Nuclear receptor ROR-gamma, 2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide
著者zhang, Y., Li, C.C., wu, X.S.
登録日2018-12-28
公開日2019-05-01
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
J.Med.Chem., 62, 2019
6ITH
  • Download 6ith
  • View 6ith
Molmil generated image of 6ith
STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF SYNDECAN 2 IN MICELLES
分子名称:Syndecan-2
著者Li, Q., Ng, H.Q., Kang, C.
登録日2018-11-23
公開日2019-02-27
最終更新日2019-03-27
実験手法SOLUTION NMR
主引用文献Secondary structure and topology of the transmembrane domain of Syndecan-2 in detergent micelles.
FEBS Lett., 593, 2019
6IQD
  • Download 6iqd
  • View 6iqd
Molmil generated image of 6iqd
CRYSTAL STRUCTURE OF ALCOHOL DEHYDROGENASE FROM GEOBACILLUS STEAROTHERMOPHILUS
分子名称:Alcohol dehydrogenase, ZINC ION
著者Xue, S., Feng, Y., Guo, X., Zhao, Z.
登録日2018-11-07
公開日2019-06-05
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Characterization of the substrate scope of an alcohol dehydrogenase commonly used as methanol dehydrogenase.
Bioorg.Med.Chem.Lett., 29, 2019
6IH8
  • Download 6ih8
  • View 6ih8
Molmil generated image of 6ih8
CRYSTAL STRUCTURE OF PHOSPHITE DEHYDROGENASE MUTANT I151R/P176R/M207A FROM RALSTONIA SP. 4506
分子名称:Phosphite dehydrogenase
著者Song, X., Feng, Y., Liu, Y., Zhao, Z.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6IH6
  • Download 6ih6
  • View 6ih6
Molmil generated image of 6ih6
PHOSPHITE DEHYDROGENASE MUTANT I151R/P176R/M207A FROM RALSTONIA SP. 4506 IN COMPLEX WITH NON-NATURAL COFACTOR NICOTINAMIDE CYTOSINE DINUCLEOTIDE
分子名称:Phosphite dehydrogenase, [[(2S,3S,4R,5S)-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Song, X., Feng, Y., Liu, Y., Zhao, Z.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6IH5
  • Download 6ih5
  • View 6ih5
Molmil generated image of 6ih5
CRYSTAL STRUCTURE OF PHOSPHITE DEHYDROGENASE MUTANT I151R/P176E FROM RALSTONIA SP. 4506 IN COMPLEX WITH NON-NATURAL COFACTOR NICOTINAMIDE CYTOSINE DINUCLEOTIDE
分子名称:Phosphite dehydrogenase, [[(2S,3S,4R,5S)-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Song, X., Feng, Y., Liu, Y., Zhao, Z.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.468 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6IH4
  • Download 6ih4
  • View 6ih4
Molmil generated image of 6ih4
CRYSTAL STRUCTURE OF PHOSPHITE DEHYDROGENASE MUTANT I151R/P176E FROM RALSTONIA SP. 4506
分子名称:Phosphite dehydrogenase
著者Song, X., Feng, Y., Liu, Y., Zhao, Z.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6IH3
  • Download 6ih3
  • View 6ih3
Molmil generated image of 6ih3
CRYSTAL STRUCTURE OF PHOSPHITE DEHYDROGENASE FROM RALSTONIA SP. 4506 IN COMPLEX WITH NON-NATURAL COFACTOR NICOTINAMIDE CYTOSINE DINUCLEOTIDE
分子名称:Phosphite dehydrogenase, [[(2S,3S,4R,5S)-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Song, X., Feng, Y., Zhao, Z., Liu, Y.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (1.942 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6IH2
  • Download 6ih2
  • View 6ih2
Molmil generated image of 6ih2
CRYSTAL STRUCTURE OF PHOSPHITE DEHYDROGENASE FROM RALSTONIA SP. 4506
分子名称:Phosphite dehydrogenase
著者Song, X., Zhao, Z., Liu, Y., Feng, Y.
登録日2018-09-28
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.048 Å)
主引用文献Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor
Acs Catalysis, 9, 2019
6G3C
  • Download 6g3c
  • View 6g3c
Molmil generated image of 6g3c
CRYSTAL STRUCTURE OF JAK2-V617F PSEUDOKINASE DOMAIN IN COMPLEX WITH COMPOUND 2
分子名称:Tyrosine-protein kinase, 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one, 1,2-ETHANEDIOL
著者Dekker, C., Hinniger, A.
登録日2018-03-24
公開日2019-03-27
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
Acs Chem.Biol., 14, 2019
6FWB
  • Download 6fwb
  • View 6fwb
Molmil generated image of 6fwb
CRYSTAL STRUCTURE OF MAT2A AT 1.79 ANGSTRON RESOLUTION
分子名称:S-adenosylmethionine synthase isoform type-2, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Zhou, A., Wei, Z., Bai, J., Wang, H.
登録日2018-03-06
公開日2019-03-27
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39, 2019
6EGF
  • Download 6egf
  • View 6egf
Molmil generated image of 6egf
CRYSTAL STRUCTURE OF THE INACTIVE UNPHOSPHORYLATED IRAK4 KINASE DOMAIN BOUND TO AMP-PNP
分子名称:Interleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
著者Ferrao, R., Wu, H.
登録日2018-08-19
公開日2019-02-13
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Conformational flexibility and type II inhibition of IRAK4
To Be Published
6EGE
  • Download 6ege
  • View 6ege
Molmil generated image of 6ege
CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED IRAK4 KINASE DOMAIN BOUND TO A TYPE I INHIBITOR
分子名称:Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
著者Ferrao, R., Liu, Q., Wu, H.
登録日2018-08-19
公開日2019-02-13
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Conformational flexibility and type II inhibition of IRAK4
To Be Published
6EGD
  • Download 6egd
  • View 6egd
Molmil generated image of 6egd
CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED IRAK4 KINASE DOMAIN BOUND TO A TYPE I INHIBITOR
分子名称:Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide
著者Ferrao, R., Wu, H.
登録日2018-08-19
公開日2019-02-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conformational flexibility and type II inhibition of IRAK4
To Be Published
6EGA
  • Download 6ega
  • View 6ega
Molmil generated image of 6ega
IRAK4 IN COMPLEX WITH A TYPE II INHIBITOR
分子名称:Interleukin-1 receptor-associated kinase 4, 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, SULFATE ION, ...
著者Wang, L., Wu, H.
登録日2018-08-19
公開日2019-02-20
実験手法X-RAY DIFFRACTION (2.512 Å)
主引用文献Conformational flexibility and type II inhibition of IRAK4
To Be Published
6EG9
  • Download 6eg9
  • View 6eg9
Molmil generated image of 6eg9
IRAK4 IN COMPLEX WITH PONATINIB
分子名称:Interleukin-1 receptor-associated kinase 4, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, SULFATE ION, ...
著者Wang, L., Wu, H.
登録日2018-08-19
公開日2019-02-20
実験手法X-RAY DIFFRACTION (2.414 Å)
主引用文献Conformational flexibility and type II inhibition of IRAK4
To Be Published
6D2I
  • Download 6d2i
  • View 6d2i
Molmil generated image of 6d2i
JAK2 PSEUDOKINASE V617F IN COMPLEX WITH AT9283
分子名称:Tyrosine-protein kinase, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea
著者Li, Q., Li, K., Eck, M.J.
登録日2018-04-13
公開日2019-03-20
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (3.192 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
6BTG
  • Download 6btg
  • View 6btg
Molmil generated image of 6btg
CRYSTAL STRUCTURE OF DEOXYRIBOSE-PHOSPHATE ALDOLASE BOUND WITH DHAP FROM BACILLUS THURINGIENSIS
分子名称:Fuculose phosphate aldolase, MANGANESE (II) ION, 1,3-DIHYDROXYACETONEPHOSPHATE
著者Li, Q., Bruner, S.D.
登録日2017-12-06
公開日2018-07-04
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.
Nat Commun, 9, 2018
6BTD
  • Download 6btd
  • View 6btd
Molmil generated image of 6btd
CRYSTAL STRUCTURE OF DEOXYRIBOSE-PHOSPHATE ALDOLASE FROM BACILLUS THURINGIENSIS INVOLVED IN DISPATCHING THE UBIQUITOUS RADICAL SAM ENZYME BYPRODUCT 5-DEOXYRIBOSE
分子名称:Fuculose phosphate aldolase, SULFATE ION, MANGANESE (II) ION
著者Li, Q., Bruner, S.D.
登録日2017-12-06
公開日2018-07-04
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.
Nat Commun, 9, 2018
6B9V
  • Download 6b9v
  • View 6b9v
Molmil generated image of 6b9v
CRYSTAL STRUCTURE OF A NEW DIPHOSPHATASE FROM THE PHNP FAMILY
分子名称:Beta-lactamase-like protein, MANGANESE (II) ION, PHOSPHATE ION, ...
著者Li, Q., Bruner, S.D.
登録日2017-10-11
公開日2018-10-17
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献An unusual diphosphatase from the PhnP family cleaves reactive FAD photoproducts.
Biochem.J., 475, 2018
5YRP
  • Download 5yrp
  • View 5yrp
Molmil generated image of 5yrp
CRYSTAL STRUCTURE OF THE EAL DOMAIN OF MYCOBACTERIUM SMEGMATIS DCPA
分子名称:Sensory box/response regulator, MAGNESIUM ION
著者Chen, H.J., li, N., Luo, Y., Jiang, Y.L., Zhou, C.Z., Chen, Y., Li, Q.
登録日2017-11-09
公開日2018-05-09
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
5YAT
  • Download 5yat
  • View 5yat
Molmil generated image of 5yat
CRYSTAL STRUCTURE OF MITOCHONDRIAL ALCOHOL DEHYDROGENASE ISOZYME III FROM KOMAGATAELLA PHAFFII GS115
分子名称:Mitochondrial alcohol dehydrogenase isozyme III, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Zhang, H.D., Li, Q.
登録日2017-09-01
公開日2018-03-21
実験手法X-RAY DIFFRACTION (1.745 Å)
主引用文献Investigation of structure and function of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115.
Biochim. Biophys. Acta, 1862, 2018
5XHZ
  • Download 5xhz
  • View 5xhz
Molmil generated image of 5xhz
CRYSTAL STRUCTURE ANALYSIS OF CIN85-SH3B IN COMPLEX WITH ARAP1-P2
分子名称:SH3 domain-containing kinase-binding protein 1, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ...
著者Liu, W., Yang, W.
登録日2017-04-25
公開日2018-04-11
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.319 Å)
主引用文献Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
Biochemistry, 57, 2018