4RFR

Complex structure of AlkB/rhein

Summary for 4RFR

Entry DOI	10.2210/pdb4rfr/pdb
Related	3T4H
Descriptor	Alpha-ketoglutarate-dependent dioxygenase AlkB, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, demethylation, alkb family, jellyroll fold, demethylase, nucleic acid binding, nucleus, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	22895.95
Authors	Li, Q.,Huang, Y.,Li, J.F.,Yang, C.-G. (deposition date: 2014-09-27, release date: 2016-04-06, Last modification date: 2024-02-28)
Primary citation	Li, Q.,Huang, Y.,Liu, X.,Gan, J.,Chen, H.,Yang, C.G. Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage. J.Biol.Chem., 291:11083-11093, 2016 Cited by PubMed: 27015802 DOI: 10.1074/jbc.M115.711895 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation