Author results

9NSE
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, ETHYL-ISOSELENOUREA COMPLEX
Descriptor:PROTEIN (NITRIC OXIDE SYNTHASE), ACETATE ION, ZINC ION, ...
Authors:Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-01-13
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
J.Inorg.Biochem., 81, 2000
8NSE
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, NNA COMPLEX
Descriptor:PROTEIN (NITRIC OXIDE SYNTHASE), ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-01-14
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry, 40, 2001
7NSE
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, H4B-FREE, ADMA COMPLEX
Descriptor:PROTEIN (NITRIC OXIDE SYNTHASE), ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-01-13
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of the Heme Domain of Bovine Endothelial Nitric Oxide Synthase Complexed with Arginine Analogues
To be Published
6WJV
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STRUCTURE OF THE SACCHAROMYCES CEREVISIAE POLYMERASE EPSILON HOLOENZYME
Descriptor:DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ...
Authors:Yuan, Z., Georgescu, R., Schauer, G.D., O'Donnell, M., Li, H.
Deposit date:2020-04-14
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome.
Nat Commun, 11, 2020
6WGI
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ATOMIC MODEL OF THE MUTANT OCCM (ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION) LOADED ON DNA AT 10.5 A RESOLUTION
Descriptor:DNA (34-MER), Cell division control protein 6, Origin recognition complex subunit 1, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 2020
6WGG
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ATOMIC MODEL OF PRE-INSERTION MUTANT OCCM-DNA COMPLEX(ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION)
Descriptor:Cell division cycle protein CDT1, Cell division control protein 6, Origin recognition complex subunit 1, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 2020
6WGF
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ATOMIC MODEL OF MUTANT MCM2-7 HEXAMER WITH MCM6 WHD TRUNCATION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM7, DNA replication licensing factor MCM6, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 2020
6WGC
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ATOMIC MODEL OF SEMI-ATTACHED MUTANT OCCM-DNA COMPLEX (ORC-CDC6-CDT1-MCM2-7 WITH MCM6 WHD TRUNCATION)
Descriptor:Cell division control protein 6, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 2020
6WEL
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STRUCTURE OF CGMP-UNBOUND F403V/V407A MUTANT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WEK
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STRUCTURE OF CGMP-BOUND WT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, CYCLIC GUANOSINE MONOPHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WEJ
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STRUCTURE OF CGMP-UNBOUND WT TAX-4 RECONSTITUTED IN LIPID NANODISCS
Descriptor:Cyclic nucleotide-gated cation channel, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Zheng, X., Fu, Z., Su, D., Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R.A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J., Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
6WB9
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STRUCTURE OF THE S. CEREVISIAE ER MEMBRANE COMPLEX
Descriptor:Endoplasmic reticulum membrane protein complex subunit 10, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ...
Authors:Bai, L., Li, H.
Deposit date:2020-03-26
Release date:2020-06-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the ER membrane complex, a transmembrane-domain insertase.
Nature, 2020
6VSI
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CRYSTAL STRUCTURE OF FKBP12 OF CANDIDA AURIS
Descriptor:Peptidylprolyl isomerase, SULFATE ION
Authors:Li, Z., Li, H., Hernandez, G., LeMaster, D.
Deposit date:2020-02-11
Release date:2020-04-01
Last modified:2020-04-29
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure and transient dimerization for the FKBP12 protein from the pathogenic fungus Candida auris.
Biochem.Biophys.Res.Commun., 525, 2020
6UL8
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RIP2 KINASE CATALYTIC DOMAIN COMPLEX WITH (5S,6S,8R)-2-(BENZO[D]THIAZOL-5-YL)-6-HYDROXY-4,5,6,7,8,9-HEXAHYDRO-5,8-METHANOPYRAZOLO[1,5-A][1,3]DIAZOCINE-3-CARBOXAMIDE
Descriptor:Receptor-interacting serine/threonine-protein kinase 2, (5S,6S,8R)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide, CALCIUM ION
Authors:Shewchuk, L.M., Convery, M.A.
Deposit date:2019-10-07
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6U7J
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UNCULTURED CLOSTRIDIUM SP. BETA-GLUCURONIDASE
Descriptor:Beta-glucuronidase, CALCIUM ION
Authors:Ervin, S.M., Redinbo, M.R.
Deposit date:2019-09-03
Release date:2019-10-30
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.
J.Biol.Chem., 294, 2019
6U0M
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STRUCTURE OF THE S. CEREVISIAE REPLICATIVE HELICASE CMG IN COMPLEX WITH A FORKED DNA
Descriptor:DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ...
Authors:Yuan, Z., Georgescu, R., Bai, L., Zhang, D., O'Donnell, M., Li, H.
Deposit date:2019-08-14
Release date:2020-03-25
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:DNA unwinding mechanism of a eukaryotic replicative CMG helicase.
Nat Commun, 11, 2020
6TYY
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HEDGEHOG AUTOPROCESSING MUTANT D46H
Descriptor:Protein hedgehog
Authors:Li, H., Li, Z., Wang, C., Callahan, B.P.
Deposit date:2019-08-09
Release date:2019-11-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
J.Am.Chem.Soc., 141, 2019
6SZJ
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RIP2 KINASE CATALYTIC DOMAIN COMPLEX WITH 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.
Descriptor:Receptor-interacting serine/threonine-protein kinase 2, 5-amino-1-~{tert}-butyl-3-(3-methoxyphenyl)pyrazole-4-carboxamide, CALCIUM ION
Authors:Convery, M.A., Charnley, A.K., Shewchuk, L.
Deposit date:2019-10-02
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SZE
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RIP2 KINASE CATALYTIC DOMAIN COMPLEX WITH 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXAMIDE.
Descriptor:Receptor-interacting serine/threonine-protein kinase 2, 5-Amino-1-Phenylpyrazole-4-Carboxamide, CALCIUM ION
Authors:Convery, M.A., Charnley, A.K., Shewchuk, L.
Deposit date:2019-10-02
Release date:2019-10-23
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6PTO
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STRUCTURE OF CTF4 TRIMER IN COMPLEX WITH THREE CMG HELICASES
Descriptor:DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Yuan, Z., Georgescu, R., Bai, L., Santos, R., Donnell, M., Li, H.
Deposit date:2019-07-16
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
6PTN
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STRUCTURE OF CTF4 TRIMER IN COMPLEX WITH TWO CMG HELICASES
Descriptor:DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Yuan, Z., Georgescu, R., Bai, L., Santos, R., Donnell, M., Li, H.
Deposit date:2019-07-16
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
6PTJ
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STRUCTURE OF CTF4 TRIMER IN COMPLEX WITH ONE CMG HELICASE
Descriptor:DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ...
Authors:Yuan, Z., Georgescu, R., Bai, L., Santos, R., Donnell, M., Li, H.
Deposit date:2019-07-15
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
6PSY
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CRYO-EM STRUCTURE OF S. CEREVISIAE DRS2P-CDC50P IN THE AUTOINHIBITED APO FORM
Descriptor:Probable phospholipid-transporting ATPase DRS2, Cell division control protein 50, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bai, L., Li, H.
Deposit date:2019-07-14
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nat Commun, 10, 2019
6PSX
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CRYO-EM STRUCTURE OF S. CEREVISIAE DRS2P-CDC50P IN THE PI4P-ACTIVATED FORM
Descriptor:Probable phospholipid-transporting ATPase DRS2, Cell division control protein 50, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bai, L., Li, H.
Deposit date:2019-07-14
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nat Commun, 10, 2019
6PP4
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STRUCTURE OF HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-(3-(AMINOMETHYL)-4-(PYRIDIN-3-YLMETHOXY)PHENYL)-4-METHYLQUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Chreifi, G., Li, H., Poulos, T.L.
Deposit date:2019-07-05
Release date:2020-04-29
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
J.Med.Chem., 63, 2020
167132
数据于2020-07-29公开中