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3KTA
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BU of 3kta by Molmil
Structural Basis for Adenylate Kinase Activity in ABC ATPases
Descriptor: BIS(ADENOSINE)-5'-PENTAPHOSPHATE, Chromosome segregation protein smc, MAGNESIUM ION
Authors:Lammens, A, Hopfner, K.P.
Deposit date:2009-11-24
Release date:2010-06-30
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.627 Å)
Cite:Structural Basis for Adenylate Kinase Activity in ABC ATPases.
J.Mol.Biol., 401, 2010
4HT1
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BU of 4ht1 by Molmil
Human TWEAK in complex with the Fab fragment of a neutralizing antibody
Descriptor: Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab
Authors:Lammens, A.
Deposit date:2012-10-31
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding.
Plos One, 8, 2013
4ZRQ
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BU of 4zrq by Molmil
E88 deletion mutant of CD320 in complex with TC2
Descriptor: CALCIUM ION, CD320 antigen, CYANOCOBALAMIN, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2015-05-12
Release date:2016-07-20
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of transcobalamin recognition by human CD320 receptor.
Nat Commun, 7, 2016
4ZRP
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BU of 4zrp by Molmil
TC:CD320
Descriptor: CALCIUM ION, CD320 antigen, CYANOCOBALAMIN, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2015-05-12
Release date:2016-07-20
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of transcobalamin recognition by human CD320 receptor.
Nat Commun, 7, 2016
1XEW
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BU of 1xew by Molmil
Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Descriptor: SMC protein
Authors:Lammens, A, Schele, A, Hopfner, K.-P.
Deposit date:2004-09-13
Release date:2004-12-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases
Curr.Biol., 14, 2004
1XEX
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BU of 1xex by Molmil
Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SMC protein
Authors:Lammens, A, Schele, A, Hopfner, K.-P.
Deposit date:2004-09-13
Release date:2004-12-07
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases
Curr.Biol., 14, 2004
6QEX
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BU of 6qex by Molmil
Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2019-01-08
Release date:2019-02-27
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science, 363, 2019
6QEE
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BU of 6qee by Molmil
Nanodisc reconstituted Human-mouse chimeric ABCB1 (ABCB1HM)-EQ mutant in complex with UIC2 Fab and Zosuquidar.
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ABCB1HM-EQ, ...
Authors:Alam, A.
Deposit date:2019-01-07
Release date:2019-02-27
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science, 363, 2019
6FN4
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BU of 6fn4 by Molmil
Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ...
Authors:Alam, A, Locher, K.P.
Deposit date:2018-02-02
Release date:2018-02-21
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FN1
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BU of 6fn1 by Molmil
Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Human-mouse chimeric ABCB1 (ABCBHM), UIC2 Antigen Binding Fragment Heavy Chain, ...
Authors:Alam, A, Locher, K.P.
Deposit date:2018-02-02
Release date:2018-02-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4IPY
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BU of 4ipy by Molmil
HIV capsid C-terminal domain
Descriptor: 1,2-ETHANEDIOL, Capsid protein p24
Authors:Lampel, A, Yaniv, O, Berger, O, Bachrach, E, Gazit, E, Frolow, F.
Deposit date:2013-01-10
Release date:2013-10-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A triclinic crystal structure of the carboxy-terminal domain of HIV-1 capsid protein with four molecules in the asymmetric unit reveals a novel packing interface.
Acta Crystallogr.,Sect.F, 69, 2013
1FW5
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BU of 1fw5 by Molmil
SOLUTION STRUCTURE OF MEMBRANE BINDING PEPTIDE OF SEMLIKI FOREST VIRUS MRNA CAPPING ENZYME NSP1
Descriptor: NONSTRUCTURAL PROTEIN NSP1
Authors:Lampio, A, Kilpelinen, I, Pesonen, S, Karhi, K, Auvinen, P, Somerharju, P, Kriinen, L.
Deposit date:2000-09-21
Release date:2001-09-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Membrane binding mechanism of an RNA virus-capping enzyme.
J.Biol.Chem., 275, 2001
2Q69
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BU of 2q69 by Molmil
Crystal Structure of Nak channel D66N mutant
Descriptor: CALCIUM ION, Potassium channel protein, SODIUM ION
Authors:Alam, A, Shi, N, Jiang, Y.
Deposit date:2007-06-04
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into Ca2+ specificity in tetrameric cation channels.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q6A
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BU of 2q6a by Molmil
Crystal Structure of Nak channel D66E mutant
Descriptor: CALCIUM ION, Potassium channel protein, SODIUM ION
Authors:Alam, A, Shi, N, Jiang, Y.
Deposit date:2007-06-04
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insight into Ca2+ specificity in tetrameric cation channels.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q68
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BU of 2q68 by Molmil
Crystal Structure of Nak channel D66A, S70E double mutants
Descriptor: CALCIUM ION, Potassium channel protein, SODIUM ION
Authors:Alam, A, Shi, N, Jiang, Y.
Deposit date:2007-06-04
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insight into Ca2+ specificity in tetrameric cation channels.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q67
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BU of 2q67 by Molmil
Crystal Structure of Nak channel D66A mutant
Descriptor: CALCIUM ION, Potassium channel protein, SODIUM ION
Authors:Alam, A, Shi, N, Jiang, Y.
Deposit date:2007-06-04
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insight into Ca2+ specificity in tetrameric cation channels.
Proc.Natl.Acad.Sci.Usa, 104, 2007
6W3K
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BU of 6w3k by Molmil
Structure of unphosphorylated human IRE1 bound to G-9807
Descriptor: 4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Lammens, A, Wang, W, Ferri, E, Rudolph, J.
Deposit date:2020-03-09
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
Nat Commun, 11, 2020
7B1O
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BU of 7b1o by Molmil
Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complex with compound 22
Descriptor: 4-chloranyl-N-[(1R)-1-[(1S,5R)-3-quinolin-4-yloxy-6-bicyclo[3.1.0]hexanyl]propyl]benzamide, Indoleamine 2,3-dioxygenase 1
Authors:Lammens, A, Krapp, S, Lewis, R.T, Hamilton, M.M.
Deposit date:2020-11-25
Release date:2021-09-29
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J.Med.Chem., 64, 2021
6FXN
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BU of 6fxn by Molmil
Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab
Descriptor: Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain
Authors:Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P.
Deposit date:2018-03-09
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nat Commun, 9, 2018
4ZCH
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BU of 4zch by Molmil
Single-chain human APRIL-BAFF-BAFF Heterotrimer
Descriptor: TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B
Authors:Lammens, A, Jiang, X, Maskos, K, Schneider, P.
Deposit date:2015-04-16
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J.Biol.Chem., 290, 2015
6GL3
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BU of 6gl3 by Molmil
Crystal structure of human Phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) in complex with ligand 44
Descriptor: (3~{S})-4-(6-azanyl-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-~{N}-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
Authors:Lammens, A, Augustin, M, Steinbacher, S, Reuberson, J.
Deposit date:2018-05-22
Release date:2018-08-15
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Discovery of a Potent, Orally Bioavailable PI4KIII beta Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
J. Med. Chem., 61, 2018
7SVN
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BU of 7svn by Molmil
DPP9 IN COMPLEX WITH LIGAND ICeD-1
Descriptor: (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 9
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVM
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BU of 7svm by Molmil
DPP8 IN COMPLEX WITH LIGAND ICeD-2
Descriptor: (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 8, trimethylamine oxide
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVO
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BU of 7svo by Molmil
DPP8 IN COMPLEX WITH LIGAND ICeD-1
Descriptor: (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 8, trimethylamine oxide
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVL
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BU of 7svl by Molmil
DPP9 IN COMPLEX WITH LIGAND ICeD-2
Descriptor: (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 9
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022

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