6QEX

Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol

Summary for 6QEX

• Entry DOI: 10.2210/pdb6qex/pdb
• Related: 6QEE
• EMDB information: 4536 4539
• Descriptor: Multidrug resistance protein 1, UIC2 Fab lightchain, UIC2 Fab heavy chain, ... (7 entities in total)
• Functional Keywords: abcb1, p-glycoprotein, p-gp, multidrug exporter, abc transporter, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 199531.22

Authors

Alam, A.,Locher, K.P. (deposition date: 2019-01-08, release date: 2019-02-27, Last modification date: 2021-06-02)

• Primary citation: Alam, A.,Kowal, J.,Broude, E.,Roninson, I.,Locher, K.P.; Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.; Science, 363:753-756, 2019; PubMed: 30765569; DOI: 10.1126/science.aav7102

Experimental method

ELECTRON MICROSCOPY (3.6 Å)