6QEX
Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Multidrug resistance protein 1 | polymer | 1280 | 141628.8 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (Human) | ATP-binding cassette sub-family B member 1,P-glycoprotein 1 |
| 2 | B (B) | UIC2 Fab lightchain | polymer | 220 | 24321.0 | 1 | Mus musculus | ||
| 3 | C (C) | UIC2 Fab heavy chain | polymer | 225 | 24381.3 | 1 | Mus musculus | ||
| 4 | D, E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | G, H, I, J, K... (A) | CHOLESTEROL | non-polymer | 386.7 | 16 | Chemie (CLR) | |||
| 6 | W (A) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) | |||
| 7 | X, Y (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 2 | Chemie (3PE) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
| PDB | External Database | Details |
|---|---|---|
| Ala 893 | Ser 893 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 190331.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 9200.1 | |
| All* | Total formula weight | 199531.2 |
