7SVM

DPP8 IN COMPLEX WITH LIGAND ICeD-2

Summary for 7SVM

• Entry DOI: 10.2210/pdb7svm/pdb
• Descriptor: Dipeptidyl peptidase 8, (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, trimethylamine oxide, ... (4 entities in total)
• Functional Keywords: dipeptidyl peptidase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 315758.63

Authors

Lammens, A.,Hollenstein, K.,Klein, D.J. (deposition date: 2021-11-19, release date: 2022-10-05, Last modification date: 2023-10-18)

• Primary citation: Moore, K.P.,Schwaid, A.G.,Tudor, M.,Park, S.,Beshore, D.C.,Converso, A.,Shipe, W.D.,Anand, R.,Lan, P.,Moningka, R.,Rothman, D.M.,Sun, W.,Chi, A.,Cornella-Taracido, I.,Adam, G.C.,Bahnck-Teets, C.,Carroll, S.S.,Fay, J.F.,Goh, S.L.,Lusen, J.,Quan, S.,Rodriguez, S.,Xu, M.,Andrews, C.L.,Song, C.,Filzen, T.,Li, J.,Hollenstein, K.,Klein, D.J.,Lammens, A.,Lim, U.M.,Fang, Z.,McHale, C.,Li, Y.,Lu, M.,Diamond, T.L.,Howell, B.J.,Zuck, P.,Balibar, C.J.; A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.; Acs Chem.Biol., 17:2595-2604, 2022; PubMed: 36044633; DOI: 10.1021/acschembio.2c00515

Experimental method

X-RAY DIFFRACTION (2.69 Å)