Author results

1BPB
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-06-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1BPD
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA, PHOSPHATE ION
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1BPE
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA; EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1BPX
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DNA POLYMERASE BETA/DNA COMPLEX
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H.
Deposit date:1997-04-11
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1BPY
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA AND DDCTP
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*DOC)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Pelletier, H., Prasad, R., Wilson, S.H., Kraut, J.
Deposit date:1997-04-15
Release date:1997-06-16
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1BPZ
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1CEH
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STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C.M., Zhu, H., Tsai, M.-D., Sundaralingam, M.
Deposit date:1994-11-16
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Protein Sci., 3, 1994
1EEL
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STRUCTURE OF A COMPLEX BETWEEN THE DNA SEQUENCE DCGCGAATTCGCG AND BIS[PIPERIDINO-ETHYL]-FURAMIDINE
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', 2,5-BIS-[4-[CYCLOPENTA-1,3-DIEN-5-YLAMINO-1-AMINOMETHYL]-PHEN-1-YL]FURAN
Authors:Neidle, S., Simpson, I.J.
Deposit date:2000-02-01
Release date:2000-02-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A thermodynamic and structural analysis of DNA minor-groove complex formation.
J.Mol.Biol., 300, 2000
1FDK
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CARBOXYLIC ESTER HYDROLASE (PLA2-MJ33 INHIBITOR COMPLEX)
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL
Authors:Sundaralingam, M.
Deposit date:1997-09-04
Release date:1998-10-14
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
Biochemistry, 36, 1997
1FMQ
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CYCLO-BUTYL-BIS-FURAMIDINE COMPLEXED WITH DCGCGAATTCGCG
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN
Authors:Simpson, I.J., Lee, M., Kumar, A., Boykin, D.W., Neidle, S.
Deposit date:2000-08-18
Release date:2000-09-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans
Bioorg.Med.Chem.Lett., 10, 2000
1FMS
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STRUCTURE OF COMPLEX BETWEEN CYCLOHEXYL-BIS-FURAMIDINE AND D(CGCGAATTCGCG)
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN
Authors:Simpson, I.J., Lee, M., Kumar, A., Boykin, D.W., Neidle, S.
Deposit date:2000-08-18
Release date:2000-09-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans
Bioorg.Med.Chem.Lett., 10, 2000
1HXI
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AN UNEXPECTED EXTENDED CONFORMATION FOR THE THIRD TPR MOTIF OF THE PEROXIN PEX5 FROM TRYPANOSOMA BRUCEI
Descriptor:PEROXISOME TARGETING SIGNAL 1 RECEPTOR PEX5, MAGNESIUM ION
Authors:Kumar, A., Roach, C., Hirsh, I.S., Turley, S., deWalque, S., Michels, P.A.M., Hol, W.G.J.
Deposit date:2001-01-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei.
J.Mol.Biol., 307, 2001
1JYM
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CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN
Descriptor:Peptide Deformylase, COBALT (II) ION
Authors:Kumar, A., Nguyen, K.T., Srivathsan, S., Ornstein, B., Turley, S., Hirsh, I., Pei, D., Hol, W.G.J.
Deposit date:2001-09-12
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design.
Structure, 10, 2002
1KVW
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT H48Q OF BOVINE PANCREATIC PLA2 ENZYME
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sundaralingam, M.
Deposit date:1998-04-24
Release date:1998-11-18
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1KVX
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D99A OF BOVINE PANCREATIC PLA2, 1.9 A ORTHORHOMBIC FORM
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sundaralingam, M.
Deposit date:1998-04-28
Release date:1998-11-18
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1KVY
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D49E COORDINATED TO CALCIUM
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sundaralingam, M.
Deposit date:1998-04-29
Release date:1998-11-18
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1MKT
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CARBOXYLIC ESTER HYDROLASE, 1.72 ANGSTROM TRIGONAL FORM OF THE BOVINE RECOMBINANT PLA2 ENZYME
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sundaralingam, M.
Deposit date:1997-09-06
Release date:1998-03-11
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:1.72 A resolution refinement of the trigonal form of bovine pancreatic phospholipase A2.
Acta Crystallogr.,Sect.D, 54, 1998
1MKV
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CARBOXYLIC ESTER HYDROLASE COMPLEX (PLA2 + TRANSITION STATE ANALOG COMPLEX)
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, 1-O-OCTYL-2-HEPTYLPHOSPHONYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Authors:Sundaralingam, M.
Deposit date:1997-09-13
Release date:1998-03-18
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure of the complex of bovine pancreatic phospholipase A2 with a transition-state analogue.
Acta Crystallogr.,Sect.D, 54, 1998
1NOM
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DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF MNCL2 (5 MILLIMOLAR)
Descriptor:DNA POLYMERASE BETA, MANGANESE (II) ION
Authors:Pelletier, H., Sawaya, M.R.
Deposit date:1996-04-19
Release date:1996-11-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.
Biochemistry, 35, 1996
1RL4
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PLASMODIUM FALCIPARUM PEPTIDE DEFORMYLASE COMPLEX WITH INHIBITOR
Descriptor:formylmethionine deformylase, COBALT (II) ION, (2R)-2-{[FORMYL(HYDROXY)AMINO]METHYL}HEXANOIC ACID, ...
Authors:Robien, M.A., Nguyen, K.T., Kumar, A., Hirsh, I., Turley, S., Pei, D., Hol, W.G.J.
Deposit date:2003-11-24
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:An improved crystal form of Plasmodium falciparum peptide deformylase.
Protein Sci., 13, 2004
1RQC
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CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN
Descriptor:formylmethionine deformylase, COBALT (II) ION
Authors:Robien, M.A., Nguyen, K.T., Kumar, A., Hirsh, I., Turley, S., Pei, D., Hol, W.G.
Deposit date:2003-12-04
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An improved crystal form of Plasmodium falciparum peptide deformylase
Protein Sci., 13, 2004
1UNE
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CARBOXYLIC ESTER HYDROLASE, 1.5 ANGSTROM ORTHORHOMBIC FORM OF THE BOVINE RECOMBINANT PLA2
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sundaralingam, M.
Deposit date:1997-11-05
Release date:1998-05-06
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-resolution refinement of orthorhombic bovine pancreatic phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1VZK
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A THIOPHENE BASED DIAMIDINE FORMS A "SUPER" AT BINDING MINOR GROOVE AGENT
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, MAGNESIUM ION
Authors:Mallena, S., Lee, M.P.H., Bailly, C., Neidle, S., Kumar, A., Boykin, D.W., Wilson, W.D.
Deposit date:2004-05-20
Release date:2004-10-25
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent
J.Am.Chem.Soc., 142, 2004
1YWV
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CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-18
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXS
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CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005